2-Amino-5-bromo-3-(hydroxymethyl)pyridine Chemical Properties

Melting point:

137-140°C

Boiling point:

343.5±37.0 °C(Predicted)

Density 

1.766±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Acetone, Ethyl Acetate, Methanol

pka

13.16±0.10(Predicted)

form 

Solid

color 

Off-white to yellow

CAS DataBase Reference

335031-01-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933399990

2-Amino-5-bromo-3-(hydroxymethyl)pyridine Usage And Synthesis

Uses

2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%).

2-Amino-5-bromo-3-(hydroxymethyl)pyridine(335031-01-1)Related Product Information

• 2-Amino-5-bromopyridine
• (5-BROMO-PYRIDIN-3-YL)-METHANOL
• 2-Amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide
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• 5-BROMO-6-METHYL-2-METHYLAMINO-NICOTINIC ACID
• IFLAB-BB F2124-0031
• ETHYL 2-AMINO-5-BROMONICOTINATE
• 2-AMINO-5-BROMO-4-METHYL NICOTINIC ACID HCL
• methyl 5-bromo-2-morpholinonicotinate
• 5-bromo-2-piperidinonicotinic acid
• Methyl 2-amino-5-bromonicotinate
• methyl 5-bromo-2-piperidinonicotinate
• IFLAB-BB F2124-0032
• tert-Butyl 4-[5-bromo-3-(methoxycarbonyl)pyridin-2-yl]piperazine-1-carboxylate
• 2-Amino-5-bromo-3-(hydroxymethyl)pyridine