1-(Naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hydrochloride Chemical Properties

Melting point:

>189°C (dec.)

Flash point:

9℃

storage temp. 

Refrigerator

solubility 

Methanol (Slightly)

form 

Solid

color 

Pale Yellow to Pale Beige

Major Application

forensics and toxicology

InChI

1S/C19H23NO.ClH/c1-2-7-18(20-12-5-6-13-20)19(21)17-11-10-15-8-3-4-9-16(15)14-17;/h3-4,8-11,14,18H,2,5-7,12-13H2,1H3;1H

InChIKey

SIOVYKZRZLWQSY-UHFFFAOYSA-N

SMILES

CCCC(N1CCCC1)C(C2=CC(C=CC=C3)=C3C=C2)=O.[H]Cl

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

1

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1

DEA Controlled Substances

CSCN: 1258
CSA SCH: Schedule I
NARC: No

1-(Naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one hydrochloride Usage And Synthesis

Description

Pyrovalerone is a psychoactive compound with stimulatory effects. It is a controlled drug that has been found as a contaminant in products sold as bath salts. Naphyrone (hydrochloride) is an analog of pyrovalerone that is characterized by the substitution of the methylphenyl group of pyrovalerone with a naphthyl group. Naphyrone potently inhibits dopamine, serotonin, and norepinephrine transporters (IC₅₀ = 20, 33, and 136 nM, respectively). Naphyrone, like pyrovalerone, has been detected in bath salt-type products. This compound is intended for forensic and research purposes.

Chemical Properties

Pale Yellow Solid

Uses

A Pyrovalerone (P997750) analog as selective dopamine transporter inhibitors.

References

[1] PETER C. MELTZER. 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) Analogues: A Promising Class of Monoamine Uptake Inhibitors[J]. Journal of Medicinal Chemistry, 2006, 49 4: 1420-1432. DOI: 10.1021/jm050797a
[2] LAURIANE TREMEAU-CAYEL . A comparison of single quadrupole mass detection and diode array ultraviolet detection interfaced to ultra-high performance supercritical chromatography for the quantitative analysis of synthetic cathinones[J]. Journal of Chromatography B, 2018, 1091: Pages 96-100. DOI: 10.1016/j.jchromb.2018.05.035