6,7-Dimethoxy-N-(4-phenoxyphenyl)-
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Basic information
- Product Name:
- 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- Synonyms:
-
- 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- Src I1
- SKI-1
- Src Inhibitor-1
- Src-l1
- ANTI-HHAT (N-TERM) antibody produced in rabbit
- HHAT
- MART2
- CAS:
- 179248-59-0
- MF:
- C22H19N3O3
- MW:
- 373.4
- Product Categories:
-
- Amines
- Aromatics
- Heterocycles
- Inhibitors
- Mol File:
- 179248-59-0.mol
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- white powder
- color
- White or off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Usage And Synthesis
Description
Src-I1 (179248-59-0) is a potent and competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50‘s = 44 nM for Src and 88 nM for Lck). Src-I1 also inhibits VEGFR2 (IC50 = 320 nM).
Uses
Src Kinase inhibitor 1 lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy
Uses
Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.
Definition
ChEBI: Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether.
General Description
A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 μM, respectively).
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
1) Tian et al. (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines; Biochem. 40 7084 2) Bain et al. (2007) The selectivity of protein kinase inhibitors: a further update; Biochem. J. 408 297
6,7-Dimethoxy-N-(4-phenoxyphenyl)-Supplier
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