6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- Product Name
- 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- CAS No.
- 179248-59-0
- Chemical Name
- 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- Synonyms
- Edr;HHAT;HB-1;Mar2;MART2;SKI-1;MEF3L;Src I1;Src-l1;Src Inhibitor-1
- CBNumber
- CB22508388
- Molecular Formula
- C22H19N3O3
- Formula Weight
- 373.4
- MOL File
- 179248-59-0.mol
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- white powder
- color
- White or off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- S2075
- Product name
- Src Inhibitor-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $174
- Updated
- 2024/03/01
- Product number
- SAB1303011
- Product name
- ANTI-HHAT (N-TERM) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μL
- Price
- $481
- Updated
- 2024/03/01
- Product number
- SAB5300036
- Product name
- Monoclonal Anti-PEG10 antibody produced in mouse
- Purity
- clone 4C10A7, ascites fluid
- Packaging
- 100μL
- Price
- $503
- Updated
- 2023/01/07
- Product number
- SAB5300035
- Product name
- Monoclonal Anti-PEG10 antibody produced in mouse
- Purity
- clone 1B1C4, ascites fluid
- Packaging
- 100μL
- Price
- $503
- Updated
- 2023/01/07
- Product number
- J67242
- Product name
- Src Inhibitor-1
- Purity
- 98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Chemical Properties,Usage,Production
Description
Src-I1 (179248-59-0) is a potent and competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50‘s = 44 nM for Src and 88 nM for Lck). Src-I1 also inhibits VEGFR2 (IC50 = 320 nM).
Uses
Src Kinase inhibitor 1 lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy
Uses
Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.
Definition
ChEBI: Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether.
General Description
A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 μM, respectively).
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
1) Tian et al. (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines; Biochem. 40 7084 2) Bain et al. (2007) The selectivity of protein kinase inhibitors: a further update; Biochem. J. 408 297
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6,7-Dimethoxy-N-(4-phenoxyphenyl)- manufacturers
- Product
- 46,7-Dimethoxy-N-(4-phenoxyphenyl)- 179248-59-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25