ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > CX-3543
CX-3543
CX-3543 Basic information
- Product Name:
- CX-3543
- Synonyms:
-
- CX-3543
- 2-(4-((R)-1-Methylpyrrolidin-2-yl)butanoyl)-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazin-3-one
- 5-Fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
- Itarnafloxin
- Quarfloxacin
- Quarfloxin (CX-3543)
- Quarfloxin
- CX 3543; QUARFLOXACIN; CX3543; CX-3543
- CAS:
- 865311-47-3
- MF:
- C35H33FN6O3
- MW:
- 604.67
- Mol File:
- 865311-47-3.mol
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CX-3543 Chemical Properties
- Boiling point:
- 845.3±65.0 °C(Predicted)
- Density
- 1.44
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 11.46±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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CX-3543 Usage And Synthesis
Uses
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].
Definition
ChEBI: Itarnafloxin is a phenoxazine.
References
[1] Hald ?H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12. DOI:10.1038/s41388-018-0611-7
CX-3543Supplier
shanghai cooperpharm co.,LTD .
- Tel
- +86-021-58975553
- sales@cooperpharm.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185;
- sales-cpd@caerulumpharma.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Amatek Scientific Co. Ltd.
- Tel
- 0512-56316828
- info@amateksci.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com