CB 30865 Chemical Properties

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

Store at 0-8 °C

solubility 

DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

form 

Powder

pka

14.31±0.46(Predicted)

color 

White to off-white

CB 30865 Usage And Synthesis

Uses

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range)[1][2]. CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664. DOI:10.1016/j.chembiol.2010.05.008
[2] Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. DOI:10.1002/(sici)1097-0320(19980901)33:13.0.co;2-9