ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > S-EMCA
S-EMCA
S-EMCA Basic information
- Product Name:
- S-EMCA
- Synonyms:
-
- 6α-Ethyl-23(S)-Methylcholic acid
- INT-777
- S-EMCA
- 6alpha-Ethyl-23(S)-methylcholic acid
- 6a-Ethyl-23(S)-methylcholic acid
- CS-1212
- INT-777, S-EMCA
- Cholane-23-carboxylic acid, 6-ethyl-3,7,12-trihydroxy-, (3α,5β,6α,7α,12α,23S)-
- CAS:
- 1199796-29-6
- MF:
- C27H46O5
- MW:
- 450.65114
- Mol File:
- 1199796-29-6.mol
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S-EMCA Chemical Properties
- Melting point:
- 150-152℃
- Boiling point:
- 602.8±55.0 °C(Predicted)
- Density
- 1.128±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:30.0(Max Conc. mg/mL);66.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);56.58(Max Conc. mM)
Ethanol:37.5(Max Conc. mg/mL);83.21(Max Conc. mM) - pka
- 4.80±0.21(Predicted)
- form
- Powder
- color
- White to yellow
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S-EMCA Usage And Synthesis
Uses
INT 777 is an inhibitor of TGR5 receptor, which is a transmembrane G protein-coupled receptor expressed in brown adipose tissue and muscle and activated by bile acid.
in vivo
INT-777 (1 μM/min/kg, p.o.) has a potent choleretic effect, prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its chole-hepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice[1]. INT-777 (30 mg/kg/day, p.o.) increases energy expenditure and reduces hepatic steatosis and obesity upon high-fat feeding in TGR5-Tg mice[2].
S-EMCASupplier
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd Gold
- Tel
- 19066311943
- 815989315@qq.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185;
- sales-cpd@caerulumpharma.com
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com