PU-WS13 Chemical Properties

Boiling point:

617.4±65.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL

form 

Powder

pka

10.15±0.29(Predicted)

color 

White to off-white

PU-WS13 Usage And Synthesis

Description

PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC₅₀ = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC₅₀s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.

Uses

PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments.

IC 50

GRP94: 0.22 μM (EC₅₀); HSP90α: 27.3 μM (EC₅₀); HSP90β: 41.8 μM (EC₅₀); TRAP-1: 7.3 μM (EC₅₀)