XCT Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

WGK 1

Storage Class

12 - Non Combustible Liquids

XCT Usage And Synthesis

Uses

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Biological Activity

Solute carrier family 7, membrane 11 (SLC7A11) or xCT participates in glutathione homeostasis, th at helps to guard the cells against oxidative stress. It is involved in the pathogenesis of malignant tumors. SLC7A11 is associated with triple negative breast cancer and glioblastoma (GBM).

XCT()Related Product Information

• H-2Db&B2M
• SIRP alpha
• IBA1
• 4-HYDROXYPHENYLRETINAMIDE
• GLY-PHE P-NITROANILIDE
• Tenascin C
• ILDR2
• Hemagglutinin 1
• Integrin α9β1
• SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-LYS-TYR-GLU-PRO-PHE