5-CHLORO-2-HYDROXYBENZONITRILE Chemical Properties

Melting point:

152-154°C

Boiling point:

269.4±25.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

6.72±0.18(Predicted)

Appearance

Light brown to off-white Solid

CAS DataBase Reference

13589-72-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38-36

Safety Statements 

26-36/37/39

RIDADR 

3276

HS Code 

2926907090

5-CHLORO-2-HYDROXYBENZONITRILE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5-chloro-2-hydroxybenzonitrile from 5-chlorosalicylaldehyde is as follows: 1. 5-Chloro-2-hydroxybenzaldehyde (300 g, 1.92 mol) was suspended in water (4.5 L) with hydroxylamine-O-sulfonic acid (260 g, 2.30 mol) at room temperature. 2. The reaction mixture was stirred at 60 °C for 7 hours. 3. Upon completion of the reaction, water (3 L) was added to the mixture, which was subsequently chilled with ice. 4. The precipitated crystals were collected by filtration and washed with 1.5 L of water. 5. The resulting crystals were re-suspended in 1.5 L of water, filtered and washed with water. 6. 6. Finally, the crystals were tray dried at 50 °C for 22 h to give 272 g of 5-chloro-2-hydroxybenzonitrile (white crystals, yield: 93%). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 6.94 (1H, d, J = 8.8 Hz), 7.42 (1H, dd, J = 8.8,2.9 Hz), 7.47 (1H, d, J = 2.9 Hz).

References

[1] Patent: WO2006/115130, 2006, A1. Location in patent: Page/Page column 53-54
[2] Patent: US2007/117866, 2007, A1
[3] Gazzetta Chimica Italiana, 1959, vol. 89, p. 1009,1013
[4] Journal of Molecular Recognition, 2012, vol. 25, # 6, p. 352 - 360
[5] Journal of Organic Chemistry, 2015, vol. 80, # 2, p. 1229 - 1234

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