2-CHLORO-4-HYDROXYBENZONITRILE Chemical Properties

Melting point:

160 °C (dec.)(lit.)

Boiling point:

323.2±27.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

6.88±0.18(Predicted)

form 

powder

color 

White

InChIKey

BDDVAWDNVWLHDQ-UHFFFAOYSA-N

CAS DataBase Reference

3336-16-1

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

2926907090

MSDS

• Language:English Provider:SigmaAldrich

2-CHLORO-4-HYDROXYBENZONITRILE Usage And Synthesis

Uses

2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.

Synthesis

Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C).

References

[1] Patent: US4424371, 1984, A

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