2-CHLORO-4-METHOXYBENZONITRILE Chemical Properties

Melting point:

71-75°C

Boiling point:

296.6±20.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

Hazard Note 

Irritant

HS Code 

2926907090

2-CHLORO-4-METHOXYBENZONITRILE Usage And Synthesis

Chemical Properties

Off-white crystalline

Synthesis

General procedure for the synthesis of 2-chloro-4-methoxybenzonitrile from 2-chloro-4-hydroxybenzonitrile and iodomethane: To a stirred solution of 2-chloro-4-hydroxybenzonitrile (2.5 g, 16 mmol) in DMF (25 mL) was slowly added NaH (0.431 g, 18.0 mmol) at 0 °C. After 30 min, iodomethane (3.47 g, 24.4 mmol), followed by continued stirring of the reaction mixture for 1 h at room temperature. After completion of the reaction, the reaction mixture was quenched with ice water and extracted with ether. The organic layer was washed sequentially with water and saturated NaCl solution, dried over Na2SO4 and concentrated in vacuum to afford the target product 2-chloro-4-methoxybenzonitrile as a brown solid (2.7 g, 98% yield).

References

[1] Patent: WO2010/65760, 2010, A1. Location in patent: Page/Page column 133-134
[2] Patent: WO2006/8046, 2006, A1. Location in patent: Page/Page column 47

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