2-CHLORO-4-METHOXYPHENOL Chemical Properties

Melting point:

41-44 °C(lit.)

Boiling point:

241°C (rough estimate)

Density 

1.153 g/mL at 25 °C(lit.)

Flash point:

185 °F

storage temp. 

Sealed in dry,2-8°C

form 

Crystalline Low Melting Solid

pka

8.98±0.18(Predicted)

Specific Gravity

1.153

color 

White to light yellow

BRN 

1936412

CAS DataBase Reference

18113-03-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29071990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-CHLORO-4-METHOXYPHENOL Usage And Synthesis

Chemical Properties

WHITE TO LIGHT YELLOW CRYST. LOW MELTING SOLID

Synthesis

General procedure for the synthesis of 2-chloro-4-methoxyphenol from 4,4-dimethoxycyclohexa-2,5-dien-1-one: 4,4-dimethoxycyclohexa-2,5-dien-1-one (1.0 mmol) was added to the reaction vessel, followed by the addition of a solution of 1,4-dioxane in 4N HCl (0.5 mL, 2 mmol) dropwise. The yellow color of the reaction mixture faded rapidly. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was diluted with ethyl acetate (10 mL) and washed with saturated aqueous NaHCO3 solution (5 mL). The organic layer was dried with anhydrous Na2SO4, filtered and concentrated to give 2-chloro-4-methoxyphenol in 95% yield. If necessary, it can be purified by column chromatography using ethyl acetate/hexane gradient elution.

References

[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 18, p. 2854 - 2858
[2] Tetrahedron Letters, 2016, vol. 57, # 1, p. 15 - 19

2-CHLORO-4-METHOXYPHENOL(18113-03-6)Related Product Information

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• 2-CHLORO-4-METHOXYBENZONITRILE
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• NAPHTHOL AS-LC ACETATE
• 1-CHLORO-2,5-DIETHOXYBENZENE
• Naphthol AS-LC
• REMASTRAL BLUE FFRL
• 2-Chloro-1,4-dimethoxybenzene
• 2-CHLORO-5-METHOXYPHENOL,2-Chloro-5-methoxyphenol 98%
• 4-CHLORO-2-METHOXYPHENOL,4-CHLORO-2-METHOXYPHENOL, TECH.
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• 2-(BETA-D-GALACTOSIDOXY)NAPHTHOL AS-LC
• 4-CHLORO-2,5-DIMETHOXYBENZONITRILE
• AMINOCHLOROHYDROQUINONE DIMETHYL ETHER