ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > M2I-1
M2I-1
M2I-1 Basic information
- Product Name:
- M2I-1
- Synonyms:
-
- 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
- M2I1;M2I 1;M2I-1
- M2I-1
- Mad2 inhibitor-1 (M2I-1)
- Mad2 inhibitor-1
- 4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-
- PPI,M2I-1,M2I1,inhibit,M-2I-1,interaction,protein-protein,Cdc20,Inhibitor,Mad2
- M2I-1, 10 mM in DMSO
- CAS:
- 312271-03-7
- MF:
- C19H24N4O4S
- MW:
- 404.48
- Product Categories:
-
- API
- Mol File:
- 312271-03-7.mol
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M2I-1 Chemical Properties
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble
- form
- A crystalline solid
- pka
- 4.79±0.20(Predicted)
- color
- Yellow to orange
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M2I-1 Usage And Synthesis
Uses
M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC)[1].
Biological Activity
Cell permeable: yes', 'Primary Target
Mad2', 'Reversible: yes
References
[1] Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666. DOI:10.1021/acschembio.5b00121
M2I-1Supplier
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
Guangzhou Zhiya Chemdrugs Co.,Ltd
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- 18122150900
- sculk28@163.com
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com