7-(2-HYDROXYETHYL)THEOPHYLLINE Chemical Properties

Melting point:

163°C

Boiling point:

365.61°C (rough estimate)

Density 

1.3055 (rough estimate)

refractive index 

1.6300 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

H₂O: Solutions may be stored for several days at 4°C.soluble

form 

solid

pka

14.48±0.10(Predicted)

color 

white

Water Solubility 

2.991g/L(temperature not stated)

Merck 

14,3878

CAS DataBase Reference

519-37-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

36-36/37-26

WGK Germany 

3

RTECS 

XH5850000

HS Code 

2939590000

MSDS

• Language:English Provider:SigmaAldrich

7-(2-HYDROXYETHYL)THEOPHYLLINE Usage And Synthesis

Chemical Properties

White Solid

Originator

Duolip,Merckle,W. Germany,1981

Uses

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

Uses

Cardiac analeptic;Phosphodiesterase inhibitor

Uses

An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

Definition

ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)Related Product Information

• Tazifylline
• PROXYPHYLLINE
• Theophylline-7-acetic acid
• Diprophylline
• Doxofylline
• Xanthinol nicotinate
• ETOFYLLINE CLOFIBRATE
• 7-(2-HYDROXYETHYL)THEOPHYLLINE
• Theophylline
• 1,3-DIMETHYL-7-(OXIRAN-2-YLMETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-CHLORO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-[2-(4-CHLOROPHENOXY)ETHYL]-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• ETHYL 2-(8-CHLORO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE
• 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-MORPHOLINO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• ETHYL 2-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE
• 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-NITRO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE