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(2S)-Bornane-10,2-sultam

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(2S)-Bornane-10,2-sultam Basic information

Product Name:
(2S)-Bornane-10,2-sultam
Synonyms:
  • (7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide
  • (2S)-Borne-10,2-sultam
  • L-2,10-Camphorsultam,99%e.e.
  • (2S)-BORNANE-10,2-SULTAM
  • (1R)-(+)-2,10-CAMPHORSULTAM
  • (1R)-2,10-CAMPHORSULTAM
  • (1R,2S)-(+)-2,10-CAMPHORSULTAM
  • (1R,5S)-10,10-DIMETHYL-3-THIA-4-AZATRICYCLO[5.2.1.01,5]DECANE 3,3-DIOXIDE
CAS:
108448-77-7
MF:
C10H17NO2S
MW:
215.31
Product Categories:
  • chiral
  • Asymmetric Synthesis
  • Bicyclic Monoterpenes
  • Biochemistry
  • Sulfur Compounds (for Synthesis)
  • Synthetic Organic Chemistry
  • Terpenes
  • Peptide
Mol File:
108448-77-7.mol
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(2S)-Bornane-10,2-sultam Chemical Properties

Melting point:
185-187 °C(lit.)
alpha 
33 º (c=4.9, CHCl3)
Boiling point:
324.8±25.0 °C(Predicted)
Density 
1.1469 (rough estimate)
refractive index 
31 ° (C=1, CHCl3)
storage temp. 
Sealed in dry,Room Temperature
solubility 
almost transparency in Chloroform
form 
powder to crystal
pka
11.05±0.40(Predicted)
color 
White to Almost white
optical activity
[α]20/D +32°, c = 5 in chloroform
BRN 
4675755
InChI
InChI=1S/C10H17NO2S/c1-9(2)7-3-4-10(9)6-14(12,13)11-8(10)5-7/h7-8,11H,3-6H2,1-2H3/t7-,8-,10-/m0/s1
InChIKey
DPJYJNYYDJOJNO-CFGJQEBVSA-N
SMILES
N1[C@]2([H])[C@@]3(C(C)(C)[C@]([H])(C2)CC3)CS1(=O)=O
CAS DataBase Reference
108448-77-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HS Code 
29242990

MSDS

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(2S)-Bornane-10,2-sultam Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

(1R)-(+)-2,10-Camphorsultam has been used as a reactant in the synthesis of pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Application

(2S)-Bornane-10,2-sultam is a pharmaceutical intermediate compound that can be used to synthesize sulfonamide drugs.  (2R)-Bornane-10,2-sultam can be used as a chiral auxiliary to perform intramolecular 1,3-dipolar cycloadditions to generate bridged and fused cycloadditions with complete diastereocontrol.  Reduction of fused isoxazolidines can generate 1-azaspiro[4.5]decane, which is a potential intermediate in the asymmetric synthesis of cylindrosin alkaloids[1].

Purification Methods

The (-)-enantiomer is recrystallised from 95% EtOH and dried in a vacuum desiccator. It dissolves in dilute aqueous NaOH and can be precipitated without hydrolysis by acidifying. It forms the N-Na salt in EtOH (by addition of Na to the EtOH solution), and the salt can be methylated with MeI to give the (-)-N-Me lactam with m 80o after recrystallisation from hot H2O and has []D -59.6o (c 5, CHCl3) [Shriner et al. J Am Chem Soc 60 2794 1938]. [Oppolzer et al. Helv Chim Acta 69 1142 1986, Weismiller et al. Org Synth 69 154 1955, Beilstein 27 III/IV 1007.]

References

[1] MARK C BAGLEY; Wolfgang O. Asymmetric synthesis of 1-azaspiro[4.5]decanes via intramolecular dipolar cycloaddition of nitrones containing the bornane-10,2-sultam chiral auxiliary[J]. Tetrahedron, asymmetry, 2000. DOI:10.1016/S0957-4166(00)00205-6.

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