(2S)-Bornane-10,2-sultam
(2S)-Bornane-10,2-sultam Basic information
- Product Name:
- (2S)-Bornane-10,2-sultam
- Synonyms:
-
- (7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide
- (2S)-Borne-10,2-sultam
- L-2,10-Camphorsultam,99%e.e.
- (2S)-BORNANE-10,2-SULTAM
- (1R)-(+)-2,10-CAMPHORSULTAM
- (1R)-2,10-CAMPHORSULTAM
- (1R,2S)-(+)-2,10-CAMPHORSULTAM
- (1R,5S)-10,10-DIMETHYL-3-THIA-4-AZATRICYCLO[5.2.1.01,5]DECANE 3,3-DIOXIDE
- CAS:
- 108448-77-7
- MF:
- C10H17NO2S
- MW:
- 215.31
- Product Categories:
-
- chiral
- Asymmetric Synthesis
- Bicyclic Monoterpenes
- Biochemistry
- Sulfur Compounds (for Synthesis)
- Synthetic Organic Chemistry
- Terpenes
- Peptide
- Mol File:
- 108448-77-7.mol
(2S)-Bornane-10,2-sultam Chemical Properties
- Melting point:
- 185-187 °C(lit.)
- alpha
- 33 º (c=4.9, CHCl3)
- Boiling point:
- 324.8±25.0 °C(Predicted)
- Density
- 1.1469 (rough estimate)
- refractive index
- 31 ° (C=1, CHCl3)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- almost transparency in Chloroform
- form
- powder to crystal
- pka
- 11.05±0.40(Predicted)
- color
- White to Almost white
- optical activity
- [α]20/D +32°, c = 5 in chloroform
- BRN
- 4675755
- InChI
- InChI=1S/C10H17NO2S/c1-9(2)7-3-4-10(9)6-14(12,13)11-8(10)5-7/h7-8,11H,3-6H2,1-2H3/t7-,8-,10-/m0/s1
- InChIKey
- DPJYJNYYDJOJNO-CFGJQEBVSA-N
- SMILES
- N1[C@]2([H])[C@@]3(C(C)(C)[C@]([H])(C2)CC3)CS1(=O)=O
- CAS DataBase Reference
- 108448-77-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 29242990
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
(2S)-Bornane-10,2-sultam Usage And Synthesis
Chemical Properties
white to light yellow crystal powde
Uses
(1R)-(+)-2,10-Camphorsultam has been used as a reactant in the synthesis of pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Application
(2S)-Bornane-10,2-sultam is a pharmaceutical intermediate compound that can be used to synthesize sulfonamide drugs. (2R)-Bornane-10,2-sultam can be used as a chiral auxiliary to perform intramolecular 1,3-dipolar cycloadditions to generate bridged and fused cycloadditions with complete diastereocontrol. Reduction of fused isoxazolidines can generate 1-azaspiro[4.5]decane, which is a potential intermediate in the asymmetric synthesis of cylindrosin alkaloids[1].
Purification Methods
The (-)-enantiomer is recrystallised from 95% EtOH and dried in a vacuum desiccator. It dissolves in dilute aqueous NaOH and can be precipitated without hydrolysis by acidifying. It forms the N-Na salt in EtOH (by addition of Na to the EtOH solution), and the salt can be methylated with MeI to give the (-)-N-Me lactam with m 80o after recrystallisation from hot H2O and has []D -59.6o (c 5, CHCl3) [Shriner et al. J Am Chem Soc 60 2794 1938]. [Oppolzer et al. Helv Chim Acta 69 1142 1986, Weismiller et al. Org Synth 69 154 1955, Beilstein 27 III/IV 1007.]
References
[1] MARK C BAGLEY; Wolfgang O. Asymmetric synthesis of 1-azaspiro[4.5]decanes via intramolecular dipolar cycloaddition of nitrones containing the bornane-10,2-sultam chiral auxiliary[J]. Tetrahedron, asymmetry, 2000. DOI:10.1016/S0957-4166(00)00205-6.
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(2S)-Bornane-10,2-sultam(108448-77-7)Related Product Information
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- (2R)-Bornane-10,2-sultam
- (1S)-(+)-10-CAMPHORSULFONAMIDE