N,O-Dimethylhydroxylamine hydrochloride Chemical Properties

Melting point:

112-115 °C

storage temp. 

Store below +30°C.

solubility 

DMSO, Methanol

form 

Crystalline Powder or Crystals

color 

White to off-white

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

BRN 

3650353

InChI

InChI=1S/C2H7NO.ClH/c1-3-4-2;/h3H,1-2H3;1H

InChIKey

USZLCYNVCCDPLQ-UHFFFAOYSA-N

SMILES

N(C)OC.Cl

CAS DataBase Reference

6638-79-5(CAS DataBase Reference)

EPA Substance Registry System

Methanamine, N-methoxy-, hydrochloride (6638-79-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38-36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29280090

MSDS

• Language:English Provider:N,O-Dimethylhydroxylamine hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N,O-Dimethylhydroxylamine hydrochloride Usage And Synthesis

Chemical Properties

N,O-Dimethylhydroxylamine hydrochloride is white to off-white crystals or crystalline powder

Uses

N,O-Dimethylhydroxylamine hydrochloride is used for preparation of an inhibitor of the NLS-derived BC peptides.

Uses

N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.

Uses

Reagent for the preparation of Weinreb amides recently used in the synthesis of 2-acyloxazoles from 2-oxazolemagnesium chloride.

Synthesis

N,O-Dimethylhydroxylamine hydrochloride was synthesised by methylation, saponification and decarboxylation reactions using chloroformate ester (I) as the starting material. The specific reaction procedure is as follows: First, hydroxylamine hydrochloride is used to treat chloroformate (I). The resulting N-ethoxycarbonylhydroxylamine (II) is then subjected to methylation. Compound (III) undergoes saponification and decarboxylation to yield N,O-Dimethylhydroxylamine hydrochloride (IV).

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