PEPSINOSTREPTIN Chemical Properties

Boiling point:

994.1±65.0 °C(Predicted)

Density 

1.125±0.06 g/cm3(Predicted)

storage temp. 

−20°C

pka

4.17±0.10(Predicted)

Safety Information

WGK Germany 

3

HS Code 

3504009000

MSDS

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PEPSINOSTREPTIN Usage And Synthesis

Uses

Pepsinostreptin is an enzyme inhibitor with the activity of inhibiting pepsin. Pepsinostreptin can form a 1:1 complex with pepsin and significantly inhibit its activity. The activity of pepsinostreptin makes it have important application potential in the study of protease inhibition and related biological processes[1].

Definition

ChEBI: Pepsinostreptin is a peptide.

Enzyme inhibitor

This statin-containing peptidomimetic (FW = 670.87 g/mol)) Structure: Isobutyryl-L-Val-L-Val-Sta-L-Ala-Sta, where Sta is statine, or (3S,4S)-4- amino-3-hydroxy-6-methylheptanoic acid, from a stain of Streptomyces forms a high-affinity complex with pepsin, inhibiting its activity. Pepsinostreptin, which is identical to pepstatin A, except for the N-terminal isobutyryl group in place of pepstatin’s isovaleryl group, probably inhibits other aspartate proteinases

References

[1] Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp DOI:10.1021/np500337m

PEPSINOSTREPTIN(51724-57-3)Related Product Information

• 6-METHYLHEPTANOIC ACID
• ACETYL-PEPSTATIN
• STATINE
• PEPSINOSTREPTIN