Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Polypeptide >  ACETYL-PEPSTATIN

ACETYL-PEPSTATIN

Basic information Safety Supplier Related

ACETYL-PEPSTATIN Basic information

Product Name:
ACETYL-PEPSTATIN
Synonyms:
  • Ac-Pepstain
  • Pepstatin A monoacetate (ester)
  • N-Acetyl-Pepstatin
  • ACETYL-PEPSTATIN
  • AC-PEPSTATIN
  • AC-VAL-VAL-(3S,4S)-STA-ALA-(3S,4S)-STA-OH
  • AC-VAL-VAL-STA-ALA-STA
  • AC-VAL-VAL-STA-ALA-STA-OH
CAS:
28575-34-0
MF:
C31H57N5O9
MW:
643.81
Product Categories:
  • Pepetides
  • peptides
  • inhibitor
Mol File:
28575-34-0.mol
More
Less

ACETYL-PEPSTATIN Chemical Properties

storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to Off-white
InChIKey
WKYBEGDEGRCZNF-AHXZNPHMNA-N
SMILES
[C@H](CC(C)C)([C@@H](O)CC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)[C@@H](O)CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)C |&1:0,5,11,16,21,30,37,r|
More
Less

Safety Information

WGK Germany 
3
HS Code 
2924190090

MSDS

More
Less

ACETYL-PEPSTATIN Usage And Synthesis

Uses

Acetyl Pepstatin is an HIV-1 protease inhibitor.

General Description

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).

Biochem/physiol Actions

Target Ki: 20 nM at pH 4.7 against HIV-1 proteinase

in vivo

Pepstatin (Pepstatin A) has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route[1].
Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats[1].

Animal Model:Pylorus ligated male Wistar rats[1]
Dosage:0.5, 1, 10 and 50 mg/kg
Administration:Oral administration, 15 minutes after pyloric ligation
Result:Effectively prevented stomach ulceration.

ACETYL-PEPSTATINSupplier

Hangzhou Peptidego Biotech Co.,Ltd. Gold
Tel
0571-87213919
Email
Eric@peptidego.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Email
sales@alabiochem.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
More
Less

ACETYL-PEPSTATIN(28575-34-0)Related Product Information