1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE Chemical Properties

Melting point:

>180°C (dec.)

Boiling point:

270-275 °C(Press: 1 Torr)

Density 

1.228±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, Refrigerator, Under inert atmosphere

solubility 

Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Slightly)

pka

5.85±0.10(Predicted)

form 

Solid

color 

White

Stability:

Hygroscopic

Major Application

pharmaceutical
pharmaceutical small molecule

InChI

1S/C30H28Cl2N2.2ClH/c31-27-15-11-25(12-16-27)29(23-7-3-1-4-8-23)33-19-21-34(22-20-33)30(24-9-5-2-6-10-24)26-13-17-28(32)18-14-26;;/h1-18,29-30H,19-22H2;2*1H

InChIKey

DLEQNCKNBPYHEY-UHFFFAOYSA-N

SMILES

Clc1ccc(cc1)C(N3CCN(CC3)C(c5ccc(cc5)Cl)c4ccccc4)c2ccccc2.Cl.Cl

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis

Uses

1,4-Bis[(4-chlorophenyl)phenylmethyl]piperazine is an impurity of Buclizine (B689450), an antiemetic agent.

1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE(346451-15-8)Related Product Information

• 1-Piperazineethanol,4-[(2-chlorophenyl)(3-chlorophenyl)methyl]-, hydrochloride (1:2)
• 2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetic acid
• N-(2,4-Dichlorophenyl)benzenamine
• 4-CHLORODIPHENYLAMINE
• Cetirizine Methyl Ester
• SNPT-1809279-00-2
• SNPT-1809278-35-0
• (R)-De(carboxyMethyl) Cetirizine Ethanol Dihydrochloride
• 4-Chlorobenzophenone
• rac Cetirizine N-Oxide > 70% by HPLC (Mixture of Diastereomers)
• Cetirizine Glycerol Ester
• Cetirizine Ethyl Ester (USP RC A)
• (RS)-2-[2-[4-[(2-Chloro-phenyl)phenylMethyl]piperazin-1-yl]ethoxy]aceticAcidDihydrochloride
• (S)-Cetirizine Dihydrochloride
• Levocetetrizine N-Oxide
• Cetirizine EP Impurity E
• 2(2-HYDROXYETHOXY)ACETAMIDE
• Cetirizine EP Impurity B(base)