(-)-BETA-HYDRASTINE
(-)-BETA-HYDRASTINE Basic information
- Product Name:
- (-)-BETA-HYDRASTINE
- Synonyms:
-
- HYDRASTINE, (-)-B-(P) (AHP Verified)
- HYDRASTINE, (-)-B-(P)
- HYDRASTINE (D-beta-)
- (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE
- 9S)-β-Hydrastine
- N-Desmethyl &beta
- (+/-)-Nor-&beta
- Hydrastine (base and/or unspecified salts)
- CAS:
- 118-08-1
- MF:
- C21H21NO6
- MW:
- 383.39
- EINECS:
- 204-233-0
- Product Categories:
-
- XYLOCAINE
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 118-08-1.mol
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(-)-BETA-HYDRASTINE Chemical Properties
- Melting point:
- 132℃
- alpha
- D20 -50° (c = 0.3 in abs alc)
- Boiling point:
- 510.32°C (rough estimate)
- Density
- 1.339±0.06 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5614 (estimate)
- storage temp.
- −20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml
- form
- A crystalline solid
- pka
- 7.8(at 25℃)
- color
- White to light yellow
- Water Solubility
- 30mg/L(20 ºC)
- CAS DataBase Reference
- 118-08-1(CAS DataBase Reference)
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MSDS
- Language:English Provider:SigmaAldrich
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(-)-BETA-HYDRASTINE Usage And Synthesis
Description
(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.
Uses
anesthetic (local), antiarrhythmic
Uses
(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.
Definition
ChEBI: A natural product found in Hydrastis canadensis.
(-)-BETA-HYDRASTINESupplier
J & K SCIENTIFIC LTD.
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- 010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
- 3bsc@sina.com
Nanjing Chemlin Chemical Co., Ltd
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- 025-83697070
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Chemsky (shanghai) International Co.,Ltd
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- 021-50135380
- shchemsky@sina.com
Sinopharm Chemical Reagent Co,Ltd.
- Tel
- 86-21-63210123
- sj_scrc@sinopharm.com
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(-)-BETA-HYDRASTINE(118-08-1)Related Product Information
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- AKOS 244-30
- TIMTEC-BB SBB006457