Basic information Safety Supplier Related

(-)-BETA-HYDRASTINE

Basic information Safety Supplier Related

(-)-BETA-HYDRASTINE Basic information

Product Name:
(-)-BETA-HYDRASTINE
Synonyms:
  • HYDRASTINE, (-)-B-(P) (AHP Verified)
  • HYDRASTINE, (-)-B-(P)
  • HYDRASTINE (D-beta-)
  • (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE
  • 9S)-β-Hydrastine
  • N-Desmethyl &beta
  • (+/-)-Nor-&beta
  • Hydrastine (base and/or unspecified salts)
CAS:
118-08-1
MF:
C21H21NO6
MW:
383.39
EINECS:
204-233-0
Product Categories:
  • XYLOCAINE
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
118-08-1.mol
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(-)-BETA-HYDRASTINE Chemical Properties

Melting point:
132℃
alpha 
D20 -50° (c = 0.3 in abs alc)
Boiling point:
510.32°C (rough estimate)
Density 
1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5614 (estimate)
storage temp. 
−20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml
form 
A crystalline solid
pka
7.8(at 25℃)
color 
White to light yellow
Water Solubility 
30mg/L(20 ºC)
CAS DataBase Reference
118-08-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
RIDADR 
1544
WGK Germany 
3
RTECS 
MU6030000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939800000

MSDS

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(-)-BETA-HYDRASTINE Usage And Synthesis

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

Uses

anesthetic (local), antiarrhythmic

Uses

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

(-)-BETA-HYDRASTINESupplier

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