(-)-BETA-HYDRASTINE

Product Name: (-)-BETA-HYDRASTINE
CAS No.: 118-08-1
Chemical Name: (-)-BETA-HYDRASTINE
Synonyms: HYDRASTINE;l-hydrastine;Hydrastine-RM;Hydrastinebase;(-)-Hydrastine;(+/-)-Nor-βquinolin-5-yl)-;(-)--Hydrastine;9S)-β-Hydrastine;(-)-B-HYDIASTINE
CBNumber: CB2456153
Molecular Formula: C21H21NO6
Formula Weight: 383.39
MOL File: 118-08-1.mol

More

Less

(-)-BETA-HYDRASTINE Property

Melting point:: 132℃
alpha: D20 -50° (c = 0.3 in abs alc)
Boiling point:: 510.32°C (rough estimate)
Density: 1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5614 (estimate)
storage temp.: −20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 7.8(at 25℃)
color: White to light yellow
Water Solubility: 30mg/L(20 ºC)
CAS DataBase Reference: 118-08-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: 1544
WGK Germany: 3
RTECS: MU6030000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2939800000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1313210
Product name: (1R,9S)-(?)-β-Hydrastine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 10mg
Price: $589
Updated: 2025/07/31

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 25mg
Price: $235
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 50mg
Price: $401
Updated: 2024/03/01

More

Less

(-)-BETA-HYDRASTINE Chemical Properties,Usage,Production

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC₅₀ = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC₅₀ value of 66.5 μM in the presence of high extracellular K⁺ levels. It also inhibits L-type and caffeine-activated store-operated Ca²⁺ channels and prevents Ca²⁺ leakage from intracellular stores.

Uses

anesthetic (local), antiarrhythmic

Uses

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

References

[1] SO KIM1. Effects of Hydrastine Derivatives on Dopamine Biosynthesis in PC12 Cells[J]. Planta medica, 2001, 67 1: 609-613. DOI: 10.1055/s-2001-17356
[2] SHOU YU YIN . Enantio-selective inhibition of (1R,9S)- and (1S,9R)-β-hydrastines on dopamine biosynthesis in PC12 cells[J]. Neuropharmacology, 2004, 47 7: Pages 1045-1052. DOI: 10.1016/j.neuropharm.2004.07.033
[3] SHOU YU YIN. Effects of (1R,9S)-beta-hydrastine on intracellular calcium concentration in PC12 cells.[J]. Biological & pharmaceutical bulletin, 2007, 30 8: 1547-1550. DOI: 10.1248/bpb.30.1547
[4] SHOU YU YIN. Inhibitory effects of (1R,9S)-β-hydrastine on calcium transport in PC12 cells[J]. Archives of Pharmacal Research, 2007, 30 1: 109-113. DOI: 10.1007/bf02977786

(-)-BETA-HYDRASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(-)-BETA-HYDRASTINE Suppliers

Canada 1 China 66 France 1 Germany 1 India 2 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 5 United States 20 Global 99

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

118-08-1, (-)-BETA-HYDRASTINERelated Search:

Cevadine veratramine menisdaurin VERATRIDINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Xanthiside daurisoline Centella asiatica whole plant (-)-BETA-HYDRASTINE Narcotine NOSCAPINE HYDROCHLORIDE (+)-BETA-HYDRASTINE HCL HYDRASTININE HCL(RG) (+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE HYDRASTININE HYDROCHLORIDE NOSCAPINE HYDROCHLORIDE HYDRATE AKOS 244-30 TIMTEC-BB SBB006457

HYDRASTINE, (-)-B-(P) (AHP Verified)

HYDRASTINE, (-)-B-(P)

HYDRASTINE (D-beta-)

(-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE

9S)-β-Hydrastine

N-Desmethyl &beta

(+/-)-Nor-&beta

Hydrastine (base and/or unspecified salts)

(1R,9S)-(-)-β-Hydrastine

(3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one

[R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone

[S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one

6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one

6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

(1R,9S)-B-hydrastine free base

Hydrastinebase

Hydrastine (10 mg)

l-beta-Hydrastine

l-hydrastine

Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-

phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso

quinolin-5-yl)-

HYDRASTINE

HYDRASTINE, (-)-B-

(-)-BETA-HYDRASTINE

(-)-B-HYDIASTINE

(1R,9S)-(-)-BETA-HYDRASTINE

(1R,9S)-BETA-HYDRASTINE

[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-

6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-

(1R,9S)-(–)-β-Hydrastine

(-)-β-Hydrastine

(-)--Hydrastine

Hydrastine (1313210)

(-)-Hydrastine

(S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

Hydrastine,Inhibitor,inhibit

Hydrastine-RM

Hydrastine, 10 mM in DMSO

118-08-1

XYLOCAINE

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals