ChemicalBook > CAS DataBase List > (-)-BETA-HYDRASTINE
(-)-BETA-HYDRASTINE
- Product Name
- (-)-BETA-HYDRASTINE
- CAS No.
- 118-08-1
- Chemical Name
- (-)-BETA-HYDRASTINE
- Synonyms
- HYDRASTINE;l-hydrastine;Hydrastinebase;(-)-Hydrastine;(+/-)-Nor-βquinolin-5-yl)-;(-)--Hydrastine;9S)-β-Hydrastine;(-)-B-HYDIASTINE;(-)-β-Hydrastine
- CBNumber
- CB2456153
- Molecular Formula
- C21H21NO6
- Formula Weight
- 383.39
- MOL File
- 118-08-1.mol
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(-)-BETA-HYDRASTINE Property
- Melting point:
- 132℃
- alpha
- D20 -50° (c = 0.3 in abs alc)
- Boiling point:
- 510.32°C (rough estimate)
- Density
- 1.339±0.06 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5614 (estimate)
- storage temp.
- −20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml
- form
- A crystalline solid
- pka
- 7.8(at 25℃)
- Water Solubility
- 30mg/L(20 ºC)
- CAS DataBase Reference
- 118-08-1(CAS DataBase Reference)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 1313210
- Product name
- (1R,9S)-(?)-β-Hydrastine
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 10mg
- Price
- $644
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22363
- Product name
- (1R,9S)-(–)-β-Hydrastine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22363
- Product name
- (1R,9S)-(–)-β-Hydrastine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22363
- Product name
- (1R,9S)-(–)-β-Hydrastine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $235
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22363
- Product name
- (1R,9S)-(–)-β-Hydrastine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $401
- Updated
- 2024/03/01
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(-)-BETA-HYDRASTINE Chemical Properties,Usage,Production
Description
(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.
Uses
anesthetic (local), antiarrhythmic
Uses
(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.
Definition
ChEBI: A natural product found in Hydrastis canadensis.
(-)-BETA-HYDRASTINE Preparation Products And Raw materials
Raw materials
Preparation Products
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118-08-1, (-)-BETA-HYDRASTINERelated Search:
menisdaurin
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(+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE
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AKOS 244-30
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