ChemicalBook > CAS DataBase List > (-)-BETA-HYDRASTINE

(-)-BETA-HYDRASTINE

Product Name
(-)-BETA-HYDRASTINE
CAS No.
118-08-1
Chemical Name
(-)-BETA-HYDRASTINE
Synonyms
HYDRASTINE;l-hydrastine;Hydrastine-RM;Hydrastinebase;(-)-Hydrastine;(+/-)-Nor-βquinolin-5-yl)-;(-)--Hydrastine;9S)-β-Hydrastine;(-)-B-HYDIASTINE
CBNumber
CB2456153
Molecular Formula
C21H21NO6
Formula Weight
383.39
MOL File
118-08-1.mol
More
Less

(-)-BETA-HYDRASTINE Property

Melting point:
132℃
alpha 
D20 -50° (c = 0.3 in abs alc)
Boiling point:
510.32°C (rough estimate)
Density 
1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5614 (estimate)
storage temp. 
−20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml
form 
A crystalline solid
pka
7.8(at 25℃)
color 
White to light yellow
Water Solubility 
30mg/L(20 ºC)
CAS DataBase Reference
118-08-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
RIDADR 
1544
WGK Germany 
3
RTECS 
MU6030000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939800000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1313210
Product name
(1R,9S)-(?)-β-Hydrastine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10mg
Price
$644
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
10mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
25mg
Price
$235
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
50mg
Price
$401
Updated
2024/03/01
More
Less

(-)-BETA-HYDRASTINE Chemical Properties,Usage,Production

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

Uses

anesthetic (local), antiarrhythmic

Uses

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

(-)-BETA-HYDRASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(-)-BETA-HYDRASTINE Suppliers

Canada 1 China 50 France 1 Germany 1 India 2 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 5 United States 19 Global 82
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973186 4009686088
Email
3193328036@qq.com
Country
China
ProdList
18338
Advantage
68
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8899
Advantage
60
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9355
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30240
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Fax
86-28-85159085 Ex:604
Email
info@aktinchem.com
Country
CHINA
ProdList
1025
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Shaanxi Pioneer Biotech Co., Ltd .
Tel
+8613259417953
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
3000
Advantage
58
Antai Fine Chemical Technology Co.,Limited
Tel
18503026267
Email
info@antaichem.com
Country
CHINA
ProdList
9636
Advantage
58
Chengdu PFID reference Technology Co., Ltd
Tel
028-82610909 15882229804
Email
pufeide@foxmail.com
Country
China
ProdList
2335
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Email
info@aktinchem.com
Country
China
ProdList
1769
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44458
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-61856358 15229202216
Fax
029-88380327
Email
1020@dideu.com
Country
China
ProdList
10007
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
Shanghai Taopu Industrial Co., LTD
Tel
18018507602 15900573766
Email
394643792@qq.com
Country
China
ProdList
3025
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Naturewill Biotechnology Co., Ltd.
Tel
18113192475 18113192475
Email
3157321941@qq.com
Country
China
ProdList
5001
Advantage
58
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
10329
Advantage
58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
9122
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
rose.shi@synzest.com
Country
China
ProdList
6210
Advantage
58
SHANGHAI ZZBIO CO., LTD.
Tel
15102117276 19921389125
Email
tech@zzbioco.com
Country
China
ProdList
12065
Advantage
58
Mensura Group Limited
Tel
18109034517
Fax
028-87362290
Email
18109034517@163.com
Country
China
ProdList
2898
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
70071
Advantage
58
Tel
58896805
Email
7993601name@qq.com
Country
CHINA
ProdList
15092
Advantage
58
Hangzhou FandaChem Co.,Ltd.
Tel
+8615858145714
Fax
+86-571-56059825
Email
FandaChem@Gmail.com
Country
China
ProdList
9214
Advantage
55
Mensura Group Limited
Tel
+8618109034517
Fax
028-87362290
Email
hkd008@vacorda.com
Country
China
ProdList
2900
Advantage
58
Chengdu Biopurify Phytochemicals Ltd.
Tel
+8618080483897
Email
sales@biopurify.com
Country
China
ProdList
3772
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43340
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Yubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
344843571@qq.com
Country
CHINA
ProdList
6318
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Lanospharma Laboratories Co.,Ltd
Tel
--
Fax
--
Email
sales@lanospharma.com
Country
China
ProdList
6329
Advantage
56

118-08-1, (-)-BETA-HYDRASTINERelated Search:

menisdaurin VERATRIDINE VERATRINE veratramine 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Xanthiside daurisoline Centella asiatica whole plant (-)-BETA-HYDRASTINE Narcotine NOSCAPINE HYDROCHLORIDE (+)-BETA-HYDRASTINE HCL HYDRASTININE HCL(RG) (+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE HYDRASTININE HYDROCHLORIDE NOSCAPINE HYDROCHLORIDE HYDRATE AKOS 244-30 TIMTEC-BB SBB006457

  • HYDRASTINE, (-)-B-(P) (AHP Verified)
  • HYDRASTINE, (-)-B-(P)
  • HYDRASTINE (D-beta-)
  • (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE
  • 9S)-β-Hydrastine
  • N-Desmethyl &beta
  • (+/-)-Nor-&beta
  • Hydrastine (base and/or unspecified salts)
  • (1R,9S)-(-)-β-Hydrastine
  • (3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one
  • [R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one
  • (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
  • [S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one
  • 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one
  • 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
  • (1R,9S)-B-hydrastine free base
  • Hydrastinebase
  • Hydrastine (10 mg)
  • l-beta-Hydrastine
  • l-hydrastine
  • Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
  • phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso
  • quinolin-5-yl)-
  • HYDRASTINE
  • HYDRASTINE, (-)-B-
  • (-)-BETA-HYDRASTINE
  • (-)-B-HYDIASTINE
  • (1R,9S)-(-)-BETA-HYDRASTINE
  • (1R,9S)-BETA-HYDRASTINE
  • [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
  • 6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
  • (1R,9S)-(–)-β-Hydrastine
  • (-)-β-Hydrastine
  • (-)--Hydrastine
  • (-)-BETA-HYDRASTINE
  • Hydrastine (1313210)
  • (-)-Hydrastine
  • (S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
  • Hydrastine,Inhibitor,inhibit
  • Hydrastine-RM
  • 118-08-1
  • XYLOCAINE
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals