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(-)-BETA-HYDRASTINE

Product Name
(-)-BETA-HYDRASTINE
CAS No.
118-08-1
Chemical Name
(-)-BETA-HYDRASTINE
Synonyms
HYDRASTINE;l-hydrastine;Hydrastinebase;(-)-Hydrastine;(+/-)-Nor-βquinolin-5-yl)-;(-)--Hydrastine;9S)-β-Hydrastine;(-)-B-HYDIASTINE;(-)-β-Hydrastine
CBNumber
CB2456153
Molecular Formula
C21H21NO6
Formula Weight
383.39
MOL File
118-08-1.mol
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(-)-BETA-HYDRASTINE Property

Melting point:
132℃
alpha 
D20 -50° (c = 0.3 in abs alc)
Boiling point:
510.32°C (rough estimate)
Density 
1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5614 (estimate)
storage temp. 
−20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml
form 
A crystalline solid
pka
7.8(at 25℃)
Water Solubility 
30mg/L(20 ºC)
CAS DataBase Reference
118-08-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
RIDADR 
1544
WGK Germany 
3
RTECS 
MU6030000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939800000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1313210
Product name
(1R,9S)-(?)-β-Hydrastine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10mg
Price
$644
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
10mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
25mg
Price
$235
Updated
2024/03/01
Cayman Chemical
Product number
22363
Product name
(1R,9S)-(–)-β-Hydrastine
Purity
≥98%
Packaging
50mg
Price
$401
Updated
2024/03/01
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(-)-BETA-HYDRASTINE Chemical Properties,Usage,Production

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

Uses

anesthetic (local), antiarrhythmic

Uses

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

(-)-BETA-HYDRASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-BETA-HYDRASTINE Suppliers

Canada 1 China 44 France 1 Germany 1 India 2 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 5 United States 18 Global 75

118-08-1, (-)-BETA-HYDRASTINERelated Search:

menisdaurin VERATRIDINE VERATRINE veratramine 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Xanthiside daurisoline Centella asiatica whole plant (-)-BETA-HYDRASTINE Narcotine NOSCAPINE HYDROCHLORIDE (+)-BETA-HYDRASTINE HCL HYDRASTININE HCL(RG) (+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE HYDRASTININE HYDROCHLORIDE NOSCAPINE HYDROCHLORIDE HYDRATE AKOS 244-30 TIMTEC-BB SBB006457

  • HYDRASTINE, (-)-B-(P) (AHP Verified)
  • HYDRASTINE, (-)-B-(P)
  • HYDRASTINE (D-beta-)
  • (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE
  • 9S)-β-Hydrastine
  • N-Desmethyl &beta
  • (+/-)-Nor-&beta
  • Hydrastine (base and/or unspecified salts)
  • (1R,9S)-(-)-β-Hydrastine
  • (3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one
  • [R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one
  • (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
  • [S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one
  • 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one
  • 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
  • (1R,9S)-B-hydrastine free base
  • Hydrastinebase
  • Hydrastine (10 mg)
  • l-beta-Hydrastine
  • l-hydrastine
  • Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
  • phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso
  • quinolin-5-yl)-
  • HYDRASTINE
  • HYDRASTINE, (-)-B-
  • (-)-BETA-HYDRASTINE
  • (-)-B-HYDIASTINE
  • (1R,9S)-(-)-BETA-HYDRASTINE
  • (1R,9S)-BETA-HYDRASTINE
  • [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
  • 6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
  • (1R,9S)-(–)-β-Hydrastine
  • (-)-β-Hydrastine
  • (-)--Hydrastine
  • (-)-BETA-HYDRASTINE
  • Hydrastine (1313210)
  • (-)-Hydrastine
  • (S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
  • Hydrastine,Inhibitor,inhibit
  • 118-08-1
  • XYLOCAINE
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals