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(2S,4R)-4-METHYLGLUTAMIC ACID

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(2S,4R)-4-METHYLGLUTAMIC ACID Basic information

Product Name:
(2S,4R)-4-METHYLGLUTAMIC ACID
Synonyms:
  • SYM 2081
  • ERYTHRO-4-METHYL-L-GLUTAMIC ACID
  • (2S,4R)-(+)-2-Amino-4-methylpentanedioic acid
  • (2S,4R)-4-METHYLGLUTAMIC ACID
  • (2S,4R)-(+)-2-AMINO-4-METHYLPENTANEDIOIC ACID 99%
  • (2S-R)-4-METHYLGLUTAMIC ACID
  • (4R)- 4-Methyl-L-glutamic Acid
  • erythro-L-4-Methylglutamic Acid
CAS:
31137-74-3
MF:
C6H11NO4
MW:
161.16
Product Categories:
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Chiral Reagents
  • Neurochemicals
Mol File:
31137-74-3.mol
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(2S,4R)-4-METHYLGLUTAMIC ACID Chemical Properties

Melting point:
178 °C
Boiling point:
287.44°C (rough estimate)
Density 
1.3482 (rough estimate)
refractive index 
1.4230 (estimate)
storage temp. 
Store at RT
solubility 
H2O: >10 mg/mL
form 
solid
pka
2.34±0.21(Predicted)
color 
white
CAS DataBase Reference
31137-74-3(CAS DataBase Reference)
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Safety Information

WGK Germany 
3

MSDS

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(2S,4R)-4-METHYLGLUTAMIC ACID Usage And Synthesis

Chemical Properties

White

Uses

A highly selective and potent agonist for kainate receptors.

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ .

(2S,4R)-4-METHYLGLUTAMIC ACIDSupplier

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