(2S,4R)-4-METHYLGLUTAMIC ACID Chemical Properties

Melting point:

178 °C

Boiling point:

287.44°C (rough estimate)

Density 

1.3482 (rough estimate)

refractive index 

1.4230 (estimate)

storage temp. 

Store at RT

solubility 

H₂O: >10 mg/mL

form 

solid

pka

2.34±0.21(Predicted)

color 

white

CAS DataBase Reference

31137-74-3(CAS DataBase Reference)

Safety Information

WGK Germany 

3

MSDS

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(2S,4R)-4-METHYLGLUTAMIC ACID Usage And Synthesis

Chemical Properties

White

Uses

A highly selective and potent agonist for kainate receptors.

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ .

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