DCG IV Chemical Properties

Boiling point:

503.9±40.0 °C(Predicted)

Density 

1.819±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at RT

solubility 

Water (Slightly)

pka

2.40±0.10(Predicted)

form 

Powder

color 

White to off-white

Water Solubility 

Soluble to 100 mM in water

DCG IV Usage And Synthesis

Uses

DCG IV (cas# 147782-19-2) is a useful research chemical.DCG IV is a group-??II metabotropic glutamate (mGlu) receptor agonist. DCG-IV protected mouse cortical neurons grown in mixed cultures against excitotoxic degeneration induced by a 10 min pulse with NMDA.

Biological Activity

Presynaptic depressant; highly potent agonist for group II mGlu receptors. Also available as part of the Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

in vivo

IC 50

mGluR2R: 0.35 μM (EC₅₀); mGluR3R: 0.09 μM (EC₅₀); mGluR1R: 389 μM (IC₅₀); mGluR5: 630 μM (IC₅₀); mGluR4R: 22.5 μM (IC₅₀); mGluR6: 39.6 μM (IC₅₀); mGluR7: 40.1 μM (IC₅₀); mGluR8: 32 μM (IC₅₀)

storage

Store at -20°C

DCG IV(147782-19-2)Related Product Information

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• cis/trans 1,2-cyclopropanedicarboxylic acid
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• DCG IV
• (3H)-DCG IV