Safety Information

WGK Germany 

3

MSDS

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4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE Usage And Synthesis

Uses

6β-Hydroxycortisone-d7 is the isotope labelled analog of 6β-Hydroxycortisone (H918450); a compound that can be used as a probe to detect inhibition of CYP3A4 in vivo.

Definition

ChEBI: 6beta-hydroxycortisone is a C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. It has a role as a probe and a human metabolite. It is a C21-steroid, a 6beta-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 21-hydroxy steroid, a 20-oxo steroid, a 17alpha-hydroxy steroid, an 11-oxo steroid, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a cortisone.

4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE(16355-28-5)Related Product Information

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