2,4-Dichloro-5-fluoropyrimidine Chemical Properties

Melting point:

37-41 °C (lit.)

Boiling point:

80 °C / 16mmHg

Density 

1.605±0.06 g/cm3(Predicted)

Flash point:

223 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Chloroform, Methanol

pka

-3.96±0.29(Predicted)

form 

Powder or Crystalline Powder or Low Melting Solid

color 

White to pale brown

Sensitive 

Moisture Sensitive

InChI

InChI=1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H

InChIKey

WHPFEQUEHBULBW-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(F)C(Cl)=N1

CAS DataBase Reference

2927-71-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34-22

Safety Statements 

26-36-37/39-45-36/37/39

RIDADR 

3261

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich

2,4-Dichloro-5-fluoropyrimidine Usage And Synthesis

Chemical Properties

2,4-Dichloro-5-fluoropyrimidine is Yellow to Orange Crystalline Solid

Uses

2,4-Dichloro-5-fluoropyrimidine is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors. It is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors.

Uses

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Flammability and Explosibility

Not classified

2,4-Dichloro-5-fluoropyrimidine(2927-71-1)Related Product Information

• 4-Bromo-2,6-difluorobenzoic acid
• 2,4-Dichloropyrimidine
• 5-Fluoropyrimidine
• Fluorocytosine
• 2-Chloro-5-fluoropyrimidine
• 2,4-Dichloro-5-methylpyrimidine
• Dichlorofluoroethane
• 4,6-Dichloro-5-fluoropyrimidine
• FMOC-D-3-Trifluoromethylphe
• 2-Fluoro-3,5-dichloropyridine
• 2,4-DICHLORO-6-ETHYL-5-FLUOROPYRIMIDINE
• 3,5-DICHLORO-4-FLUOROPYRIDINE
• 2-AMINO-4,6-DICHLORO-5-FLUOROPYRIMIDINE
• 2,4-DICHLORO-6-FLUOROPYRIMIDINE
• 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE
• Pyrimidine, 4-chloro-5-fluoro- (9CI)
• 2,4-Dichloro-5-fluoropyrimidine
• 2,4-dichloro-5-fluoro-6-methylpyrimidine