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BRL 54443

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BRL 54443 Basic information

Product Name:
BRL 54443
Synonyms:
  • BRL 54443
  • 5-HYDROXY-3-(1-METHYLPIPERIDIN-4-YL)-1H-INDOLE
  • 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
  • 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol BRL 54443
  • 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
  • 1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-
  • BRL 54443 HCl
  • BRL-54443;BRL54443
CAS:
57477-39-1
MF:
C14H18N2O
MW:
230.31
Product Categories:
  • Inhibitors
Mol File:
Mol File
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BRL 54443 Chemical Properties

Boiling point:
431.5±45.0 °C(Predicted)
Density 
1.196
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL
form 
solid
pka
10.08±0.40(Predicted)
color 
white
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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BRL 54443 Usage And Synthesis

Uses

BRL-53443 is a potent 5-HT and dopamine receptor agonist. Neuroresearch product.

Definition

ChEBI: 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles.

Biological Activity

A potent 5-ht 1E/1F receptor agonist (pEC 50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK i values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT 1E , 1F , 1A , 1B , 1D , 2A , 2B , 2C , 4 , 7 , D 2 and D 3 receptors respectively). Induces 5-HT 2A receptor-mediated mouse aortic contraction in vitro (pEC 50 = 6.52). Active in vivo .

storage

+4°C (desiccate)

References

1. a.m. brown, k. avenell, t j. young et al. brl 54443, a potent agonist with selectivity for human cloned 5-ht1e and 5-ht1f receptors. 1998. br.j.pharmacol. 123 233p.2. s. lightowler, t. stean, n. upton et al. effect of brl 54443 (3-(1-methylpiperidin-4-yl)-1h-indol-5-ol), a 5-ht1e/1f receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. 1998. br.j.pharmacol. 123 237p.3. mckune cm, watts sw. characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. j pharmacol exp ther. 2001 apr;297(1):88-95.4. janssen p, tack j, sifrim d et al. influence of 5-ht1 receptor agonists on feline stomach relaxation. eur j pharmacol. 2004 may 25;492(2-3):259-67.

BRL 54443Supplier

Shanghai Boyle Chemical Co., Ltd.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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Hangzhou Sage Chemical Co., Ltd.
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+86057186818502 13588463833
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