3-BroMo-4-fluorobenzyl alcohol Chemical Properties

Melting point:

214 °C

Boiling point:

80°C/0.5mm

Density 

1.658±0.06 g/cm3(Predicted)

refractive index 

1.5590 to 1.5630

storage temp. 

Sealed in dry,Room Temperature

pka

13.83±0.10(Predicted)

form 

Powder

color 

Yellow

Water Solubility 

soluble

CAS DataBase Reference

77771-03-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-24/25

Hazard Note 

Irritant

HS Code 

29214900

3-BroMo-4-fluorobenzyl alcohol Usage And Synthesis

Uses

3-Bromo-4-fluorobenzylamine hydrochloride is a pharmaceutical intermediate and an important intermediate for the synthesis of alkylbenzylamine derivatives.

Chemical Properties

YELLOW POWDER

Synthesis

The resulting oxime was added to a 100 mL three-necked flask with 66 mL of 15% NaOH solution, and 6.50 g of Raney nickel was added slowly in batches at a controlled temperature of 32??C, and the reaction was heated to reflux at 100 DD for 15 h. After the reaction was complete, the reaction was cooled to room temperature, and the filtration was carried out under vacuum. A small amount of water (about 5mL) was measured to wash the filtrate and the filtrate was retained. Then the filtrate was extracted with 165mL of ethyl acetate in three portions, retaining the organic oil phase layer, hydrochloric acid adjusted the pH to 1-2, and anhydrous sodium sulfate was added to it, and it was left to dry for 2 h. Vacuum filtration was carried out to obtain 3-bromo-4-fluorobenzylamine hydrochloride.

3-BroMo-4-fluorobenzyl alcohol(77771-03-0)Related Product Information

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