Ethyl bromodifluoroacetate Chemical Properties

Boiling point:

112 °C/700 mmHg (lit.)

Density 

1.583 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.387(lit.)

Flash point:

70 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Soluble in most organic solvents.

form 

Liquid

color 

Clear colorless to slightly yellow

Specific Gravity

1.583

BRN 

1906095

InChI

InChI=1S/C4H5BrF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3

InChIKey

IRSJDVYTJUCXRV-UHFFFAOYSA-N

SMILES

C(OCC)(=O)C(Br)(F)F

CAS DataBase Reference

667-27-6(CAS DataBase Reference)

NIST Chemistry Reference

Ethyl bromodifluoroacetate(667-27-6)

Safety Information

Hazard Codes 

C,F,Xi

Risk Statements 

10-34-36

Safety Statements 

26-36/37/39-45-16-27

RIDADR 

UN 2924 3/PG 2

WGK Germany 

3

Hazard Note 

Irritant/Flammable

TSCA 

No

HazardClass 

3

PackingGroup 

II

HS Code 

29159000

MSDS

• Language:English Provider:Ethyl bromodifluoroacetate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl bromodifluoroacetate Usage And Synthesis

Description

Ethyl bromodifluoroacetate, a clear to yellow liquid, is an ester of bromodifluoroacetic acid and ethyl alcohol. It is an ester that can be used to introduce the CF2 group when synthesizing chemical compounds. Ethyl bromdifluoroacetate is considered to be a good compound in the generation of compounds and for testing with other organic compounds like lactones, imines, and other amino acids.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.

Uses

Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis. A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF2CO2Et) as a difluoroacetylating reagent.

Uses

Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.

Preparation

Difluorobromoacetonitrile is taken as a raw material, and prepared through a one-pot method and subjected to alcoholysis and esterification in ethanol aqueous solution to obtain ethyl bromodifluoroacetate.Reaction equation is:
BrF2CCN→BrF2CCOOH→BrF2CCOOC2H5

Ethyl bromodifluoroacetate(667-27-6)Related Product Information

• Difluoroacetic acid
• Ethyl difluoroacetate
• BROMODIFLUOROACETIC ACID
• METHYL BROMODIFLUOROACETATE
• Cuprous iodide
• Sulfuryl chloride
• Hydrazine sulfate
• Sodium ascorbate
• METHYL DIFLUOROACETATE
• Sodium chlorodifluoroacetate
• Diethyl 2,2-difluoromalonate
• Chlorodifluoroacetic acid ethyl ester
• 2-(2-Aminoethoxy)ethanol
• Bromoacetic acid
• Ethyl fluoroacetate
• Ethyl bromofluoroacetate
• Ethyl bromodifluoroacetate
• Ethyl bromoacetate