4-CHLOROBENZO[F]ISOQUINOLINE Chemical Properties

Boiling point:

400.3±18.0 °C(Predicted)

Density 

1.312±0.06 g/cm3(Predicted)

solubility 

DMSO: soluble15mg/mL

pka

3.21±0.30(Predicted)

form 

solid

color 

off-white

InChI

1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H

InChIKey

SHQLTRRYZVBEMR-UHFFFAOYSA-N

SMILES

Clc1nccc2c1ccc3ccccc23

Safety Information

Hazard Codes 

T

Risk Statements 

25-37/38-41

Safety Statements 

26-39-45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

4-CHLOROBENZO[F]ISOQUINOLINE Usage And Synthesis

Biological Activity

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

4-CHLOROBENZO[F]ISOQUINOLINE(32081-28-0)Related Product Information

• 1-Chloroisoquinoline
• 4-CHLOROBENZO[F]ISOQUINOLINE