AMI-193 Chemical Properties

Melting point:

176 - 179°C

storage temp. 

Store at RT

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

White solid.

color 

Off-White to Pale Yellow

AMI-193 Usage And Synthesis

Uses

AMI-193 is a selective 5-HT2A and D2DR receptor antagonist. Endoplasmic reticulum (ER) stress inducer; Also, it is derived from 4-Fluorophenol (F595325), which is a fluorinated phenolic compound with various applications as an starting reagent for the synthesis of pharmaceutical goods.

Definition

ChEBI: An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spipero e but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.

Biological Activity

Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

References

[1]. czoty pw, howell ll. behavioral effects of ami-193, a 5-ht(2a)- and dopamine d(2)-receptor antagonist, in the squirrel monkey. pharmacol biochem behav, 2000, 67(2): 257-264.
[2]. ismaiel am, de los angeles j, teitler m, et al. antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-ht2- versus 5-ht1c-selective antagonist. j med chem, 1993, 36(17): 2519-2525.
[3]. luparini mr, garrone b, pazzagli m, et al. a cortical gaba-5ht interaction in the mechanism of action of the antidepressant trazodone. prog neuropsychopharmacol biol psychiatry, 2004, 28(7): 1117-1127.

AMI-193(510-74-7)Related Product Information

• Prazosin
• Agelongine
• Anpirtoline hydrochloride
• 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
• 5-DECANONE
• [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE
• 4-(aminomethyl)-N,N,1-trimethylpiperidin-4-amine
• 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE
• 3-(4-fluorophenoxy)propan-1-amine
• CHEMBRDG-BB 4015185
• AMI-193
• 4-(aminomethyl)-1-ethyl-N,N-dimethylpiperidin-4-amine