ChemicalBook > CAS DataBase List > AMI-193

AMI-193

Product Name
AMI-193
CAS No.
510-74-7
Chemical Name
AMI-193
Synonyms
R 5808;AMI-193;spiramide;Fluroxyspiramine;AMI-193, 10 mM in DMSO;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
CBNumber
CB2728009
Molecular Formula
C22H26FN3O2
Formula Weight
383.46
MOL File
510-74-7.mol
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AMI-193 Property

Melting point:
176 - 179°C
storage temp. 
Store at RT
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White solid.
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
0524
Product name
AMI-193
Purity
≥99%(HPLC)
Packaging
10
Price
$122
Updated
2021/12/16
Tocris
Product number
0524
Product name
AMI-193
Purity
≥99%(HPLC)
Packaging
50
Price
$495
Updated
2021/12/16
Usbiological
Product number
254616
Product name
AMI-193
Packaging
10mg
Price
$403
Updated
2021/12/16
TRC
Product number
A576605
Product name
AMI-193
Packaging
50mg
Price
$495
Updated
2021/12/16
ChemScene
Product number
CS-0020651
Product name
Spiramide
Purity
98.81%
Packaging
5mg
Price
$80
Updated
2021/12/16
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AMI-193 Chemical Properties,Usage,Production

Uses

AMI-193 is a selective 5-HT2A and D2DR receptor antagonist. Endoplasmic reticulum (ER) stress inducer; Also, it is derived from 4-Fluorophenol (F595325), which is a fluorinated phenolic compound with various applications as an starting reagent for the synthesis of pharmaceutical goods.

Definition

ChEBI: An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spipero e but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.

Biological Activity

Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

in vivo

AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination[2].
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments[2].
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion)[2].

Animal Model:Adult male squirrel monkeys (850-1300 g)[2]
Dosage:0.003, 0.01 mg/kg
Administration:I.m. on Tuesday, Wednesday, and Thursday the following week
Result:Decreased the response rate.
The rate-decreasing effects were reversed by cocaine.

IC 50

5-HT2 Receptor: 2 nM (Ki); D2 Receptor: 3 nM (Ki); 5-HT1A Receptor: 50 nM (Ki); D1 Receptor: 2530 nM (Ki); 5-HT1C Receptor: 4300 nM (Ki)

References

[1]. czoty pw, howell ll. behavioral effects of ami-193, a 5-ht(2a)- and dopamine d(2)-receptor antagonist, in the squirrel monkey. pharmacol biochem behav, 2000, 67(2): 257-264.
[2]. ismaiel am, de los angeles j, teitler m, et al. antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-ht2- versus 5-ht1c-selective antagonist. j med chem, 1993, 36(17): 2519-2525.
[3]. luparini mr, garrone b, pazzagli m, et al. a cortical gaba-5ht interaction in the mechanism of action of the antidepressant trazodone. prog neuropsychopharmacol biol psychiatry, 2004, 28(7): 1117-1127.

AMI-193 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMI-193 Suppliers

China 44 Germany 2 United Kingdom 2 United States 7 USA 1 Global 56
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 +86-17392581500
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
3987
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
960
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58

510-74-7, AMI-193Related Search:

Prazosin Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride 5-DECANONE [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE 4-(aminomethyl)-N,N,1-trimethylpiperidin-4-amine 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE 3-(4-fluorophenoxy)propan-1-amine CHEMBRDG-BB 4015185 AMI-193 4-(aminomethyl)-1-ethyl-N,N-dimethylpiperidin-4-amine

  • 8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE
  • 8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE
  • AMI-193
  • spiramide
  • 1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one
  • Fluroxyspiramine
  • R 5808
  • 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
  • AMI-193, 10 mM in DMSO
  • 510-74-7
  • C22H26FN3O2
  • Serotonin receptor