AMI-193

Product Name: AMI-193
CAS No.: 510-74-7
Chemical Name: AMI-193
Synonyms: R 5808;AMI-193;spiramide;Fluroxyspiramine;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
CBNumber: CB2728009
Molecular Formula: C22H26FN3O2
Formula Weight: 383.46
MOL File: 510-74-7.mol

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AMI-193 Property

Melting point:: 176 - 179°C
storage temp.: Store at RT
solubility: DMSO (Slightly), Methanol (Slightly)
form: White solid.
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 0524
Product name: AMI-193
Purity: ≥99%(HPLC)
Packaging: 10
Price: $122
Updated: 2021/12/16

Tocris

Product number: 0524
Product name: AMI-193
Purity: ≥99%(HPLC)
Packaging: 50
Price: $495
Updated: 2021/12/16

Usbiological

Product number: 254616
Product name: AMI-193
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: A576605
Product name: AMI-193
Packaging: 50mg
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-0020651
Product name: Spiramide
Purity: 98.81%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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AMI-193 Chemical Properties,Usage,Production

Uses

AMI-193 is a selective 5-HT2A and D2DR receptor antagonist. Endoplasmic reticulum (ER) stress inducer; Also, it is derived from 4-Fluorophenol (F595325), which is a fluorinated phenolic compound with various applications as an starting reagent for the synthesis of pharmaceutical goods.

Definition

ChEBI: An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spipero e but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.

Biological Activity

Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

References

[1]. czoty pw, howell ll. behavioral effects of ami-193, a 5-ht(2a)- and dopamine d(2)-receptor antagonist, in the squirrel monkey. pharmacol biochem behav, 2000, 67(2): 257-264.
[2]. ismaiel am, de los angeles j, teitler m, et al. antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-ht2- versus 5-ht1c-selective antagonist. j med chem, 1993, 36(17): 2519-2525.
[3]. luparini mr, garrone b, pazzagli m, et al. a cortical gaba-5ht interaction in the mechanism of action of the antidepressant trazodone. prog neuropsychopharmacol biol psychiatry, 2004, 28(7): 1117-1127.

AMI-193 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMI-193 Suppliers

China 36 Germany 2 United Kingdom 2 United States 7 USA 1 Global 48

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7269
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 15319487004
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 4084
Advantage: 58

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 620
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

510-74-7, AMI-193Related Search:

Prazosin Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride 5-DECANONE [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE 4-(aminomethyl)-N,N,1-trimethylpiperidin-4-amine 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE 3-(4-fluorophenoxy)propan-1-amine CHEMBRDG-BB 4015185 AMI-193 4-(aminomethyl)-1-ethyl-N,N-dimethylpiperidin-4-amine

8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE

8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE

AMI-193

spiramide

1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one

Fluroxyspiramine

R 5808

1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-

510-74-7

C22H26FN3O2

Serotonin receptor