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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride

Product Name
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
CAS No.
210821-63-9
Chemical Name
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
Synonyms
Org 12692;Org12962HCl;Org 12962 hydrochloride;1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride;1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride;Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-, hydrochloride (1:1)
CBNumber
CB02473321
Molecular Formula
C10H11ClF3N3.ClH
Formula Weight
302.126
MOL File
210821-63-9.mol
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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Property

storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble to 50 mM in water and to 100 mM in DMSO
form 
Pale yellow solid.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27675
Product name
ORG 12962 (hydrochloride)
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
27675
Product name
ORG 12962 (hydrochloride)
Packaging
50mg
Price
$703
Updated
2024/03/01
Cayman Chemical
Product number
27675
Product name
ORG 12962 (hydrochloride)
Packaging
10mg
Price
$165
Updated
2024/03/01
Cayman Chemical
Product number
27675
Product name
ORG 12962 (hydrochloride)
Packaging
25mg
Price
$380
Updated
2024/03/01
Usbiological
Product number
256116
Product name
Org 12962 hydrochloride
Packaging
10mg
Price
$418
Updated
2021/12/16
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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Chemical Properties,Usage,Production

Uses

Org 12962 Hydrochloride is a receptor agonists that helps in the anxiety models in rats.

Biological Activity

Selective 5-HT 2C receptor agonist (pEC 50 values are 7.01, 6.38 and 6.28 for 5-HT 2C , 5-HT 2A and 5-HT 2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.

in vivo

Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].

Animal Model:Male Wistar rats[3]
Dosage:0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:Had a dose-related antipanic-like effect in SD-rat.

IC 50

5-HT2C Receptor: 7.01 (pEC50); 5-HT2A Receptor: 6.38 (pEC50); 5-HT2B Receptor: 6.28 (pEC50)

1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Suppliers

China 17 United Kingdom 1 United States 6 Global 24
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58

210821-63-9, 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochlorideRelated Search:

CINANSERIN HYDROCHLORIDE 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Azasetron hydrochloride KETANSERIN TARTRATE N-DESMETHYLCLOZAPINE CGS 12066B DIMALEATE 2-METHYL-5-HYDROXYTRYPTAMINE DIHYDROERGOCRISTINE MESYLATE Agelongine Ondansetron DIBENZEPINE HCL Anpirtoline hydrochloride AMI-193 3-TROPANYL-3,5-DICHLOROBENZOATE

  • 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
  • 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride
  • Org 12962 hydrochloride
  • Org12962HCl
  • Org 12692
  • Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-, hydrochloride (1:1)
  • 210821-63-9
  • C10H11CIF3N3HCl
  • C10H11ClF3N3HCl