3-TROPANYL-3,5-DICHLOROBENZOATE

Product Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
CAS No.: 40796-97-2
Chemical Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
Synonyms: MDL-72222;MLD-72222;bemesetron;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-TROPANYL-3,5-DICHLOROBENZOATE
CBNumber: CB2317210
Molecular Formula: C15H17Cl2NO2
Formula Weight: 314.21
MOL File: 40796-97-2.mol

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3-TROPANYL-3,5-DICHLOROBENZOATE Property

Melting point:: 165 °C
Boiling point:: 406.5±45.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: 0.1 M HCl: slightly soluble
pka: 9.89±0.40(Predicted)
form: solid
color: white
Water Solubility: Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36
WGK Germany: 3
RTECS: DG7580000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J62583
Product name: 3-Tropanyl-3,5-dichlorobenzoate, 99+%
Packaging: 50mg
Price: $247
Updated: 2021/12/16

Tocris

Product number: 0640
Product name: MDL72222
Purity: ≥99%(HPLC)
Packaging: 50
Price: $149
Updated: 2021/12/16

TRC

Product number: M199805
Product name: MDL-72222
Packaging: 100mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: 255769
Product name: MDL 72222
Packaging: 50mg
Price: $389
Updated: 2021/12/16

ChemScene

Product number: CS-0013371
Product name: Bemesetron
Purity: >99.0%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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3-TROPANYL-3,5-DICHLOROBENZOATE Chemical Properties,Usage,Production

Originator

Bemesetron,Merrel Dow

Uses

Anti-emetic.

Uses

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Manufacturing Process

Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).

Therapeutic Function

Serotonin antagonist

Biological Activity

5-HT 3 antagonist.

storage

Store at RT

3-TROPANYL-3,5-DICHLOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-TROPANYL-3,5-DICHLOROBENZOATE Suppliers

China 47 Europe 2 Germany 2 Switzerland 1 United Kingdom 4 United States 12 USA 1 Global 69

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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ProdList: 27313
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4966
Advantage: 55

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-66110311 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15527
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9639
Advantage: 58

40796-97-2, 3-TROPANYL-3,5-DICHLOROBENZOATERelated Search:

Palonosetron ALOSETRON dolasetron Dolasetron mesylate Granisetron Palonosetron Hydrochloride Palonosetron Ondansetron hydrochloride ONDANSETRON FOR LC SYSTEM SUITABILITY Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Tropine 3-TROPANYL-3,5-DICHLOROBENZOATE Nortropine hydrochloride ENDO-TROPACOCAINE (8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL) BENZOATE HCL 4-BENZYLOXY-PIPERIDINE HYDROCHLORIDE

3-TROPANYL-3,5-DICHLOROBENZOATE

MDL-72222

TROPANYL 3,5-DICHLOROBENZOATE

3,5-dichloro-,8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-benzoicaci

Bemesetron (Synonyms: MDL 72222)

Bemesetron (MDL 72222)

3,5-dichloro-benzoicaci(3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yles

bemesetron

endo-8-methyl-8-azabicyclo(3.2.1)oct-3-yl3,5-dichlorobenzoate

tropyl3,5-dichlorobenzoate

tropine 3,5-dichlorobenzoate

(1β,5β)-Tropane-3α-ol 3,5-dichlorobenzoate

3,5-Dichlorobenzoic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester

Benesetron

MLD-72222

MNJNPLVXBISNSX-WDNDVIMCSA-N

(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

Benzoic acid, 3,5-dichloro-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

rel-(1R,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

40796-97-2

C15H17Cl2NO2

Analytical Standards

Analytical Chromatography Product Catalog

Forensic and Veterinary Standards

Drug Standards

Chromatography

Serotonin receptor