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Anpirtoline hydrochloride

Product Name
Anpirtoline hydrochloride
CAS No.
99201-87-3
Chemical Name
Anpirtoline hydrochloride
CBNumber
CB43037142
Molecular Formula
C10H14Cl2N2S
Formula Weight
265.2
MOL File
99201-87-3.mol
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Anpirtoline hydrochloride Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO > 10 mM
form 
White solid.
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A697853
Product name
AnpirtolineHydrochloride
Packaging
10mg
Price
$160
Updated
2021/12/16
ApexBio Technology
Product number
B6410
Product name
Anpirtolinehydrochloride
Packaging
10mg
Price
$266
Updated
2021/12/16
ApexBio Technology
Product number
B6410
Product name
Anpirtolinehydrochloride
Packaging
50mg
Price
$1127
Updated
2021/12/16
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Anpirtoline hydrochloride Chemical Properties,Usage,Production

Originator

Anpirtoline Hydrochloride,YQBio (Shanghai) Co. Ltd.

Uses

Anpirtoline Hydrochloride is a SR-1B agonist.

Manufacturing Process

2-Chloro-6-(4-piperidinylthio)pyridine:
The reaction is carried out under an argon atmosphere. 0.27 g of 80% sodium hydride (0.009 mol) are suspended in 10 ml of dimethylacetamide; the mixture is cooled with ice and then 0.615 g (0.004 mol) of solid 4- mercaptopiperidine hydrochloride are added and stirred for 10 minutes. A solution of 0.588 g (0.004 mol) of 2,6-dichloropyridine in 5 ml of dimethylacetamide are then added dropwise to this mixture and the reaction mixture is stirred for 2.5 hours at room temperature.
Working up of the reaction mixture: 25 ml of water are added dropwise with cooling, 20 ml of methylene chloride are then added, the organic phase is separated off, the aqueous phase is then extracted twice with 15 ml of methylene chloride each time, the combined organic phase is washed twice, in each case with 10 ml of water, dried with sodium sulfate, the solution is concentrated on a rotary evaporator, the residue is mixed with 10 ml of absolute ethanol and then reconcentrated.
The product which is obtained on removal of the eluant is diluted with 10 ml of ether, an equivalent quantity of HCl in isopropanol is added dropwise and the mixture is placed for several hours in a deep freezer after addition of seed crystals. The hydrochloride of the 2-chloro-6-(4-piperidinylthio)pyridine which crystallizes out is filtered off with suction, washed with ether and dried under oil pump vacuum at 50°C. Melting point of the hydrochloride 132°-133°C.

Therapeutic Function

Analgesic, Antidepressant

storage

Desiccate at +4°C

Anpirtoline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Anpirtoline hydrochloride Suppliers

EMMX Biotechnology LLC
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888-539-0666
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United States
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8447
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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Shanghai Haohong Pharmaceutical Co., Ltd.
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4008210725 4008210725
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malulu@leyan.com
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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China
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Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
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China
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TargetMol Chemicals Inc.
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4008200310
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China
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Nantong QuanYi Biotechnology Co., Ltd
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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Aladdin Scientific
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sales@aladdinsci.com
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