N-DESMETHYLCLOZAPINE
- Product Name
- N-DESMETHYLCLOZAPINE
- CAS No.
- 6104-71-8
- Chemical Name
- N-DESMETHYLCLOZAPINE
- Synonyms
- NORCLOZAPINE;Desmethylclozapine;Norclozapine (ACP-104);Normethylclozapine;N-DESMETHYLCLOZAPINE;Clozapine EP IMpurity C;Clozapine Impurity C（EP）;Norclozapine in methanol;N-Desmethylclozapine solution;Norclozapine Solution, 100ppm
- CBNumber
- CB8196019
- Molecular Formula
- C17H17ClN4
- Formula Weight
- 312.8
- MOL File
- 6104-71-8.mol
N-DESMETHYLCLOZAPINE Property
- Melting point:
- 120-125°C
- Boiling point:
- 502.6±60.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- Store at RT
- solubility
- Chloroform (Slightly), DMSO, Methanol (Slightly)
- pka
- 8.49±0.10(Predicted)
- form
- Yellow solid.
- color
- Light Yellow to Yellow
- CAS DataBase Reference
- 6104-71-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 20/22-36/37/38-39/23/24/25-23/24/25-11
- Safety Statements
- 22-36-45-36/37-16-7
- RIDADR
- 3249
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D5676
- Product name
- N-Desmethylclozapine
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- D-048
- Product name
- N-Desmethylclozapine solution
- Purity
- 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 26153
- Product name
- N-Desmethylclozapine
- Packaging
- 5mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 26153
- Product name
- N-Desmethylclozapine
- Packaging
- 100mg
- Price
- $1078
- Updated
- 2024/03/01
- Product number
- D5676
- Product name
- N-Desmethylclozapine
- Packaging
- 10mg
- Price
- $237
- Updated
- 2024/03/01
N-DESMETHYLCLOZAPINE Chemical Properties,Usage,Production
Chemical Properties
Yellow Crystalline Solid
Uses
A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.
Uses
N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.
Uses
A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.
Definition
ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
General Description
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.
Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.
Biochem/physiol Actions
N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.
storage
Room temperature
N-DESMETHYLCLOZAPINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-DESMETHYLCLOZAPINE manufacturers
- Product
- N-DESMETHYLCLOZAPINE 6104-71-8
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02