N-DESMETHYLCLOZAPINE Property

Melting point:

120-125°C

Boiling point:

502.6±60.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

Store at RT

solubility 

Chloroform (Slightly), DMSO, Methanol (Slightly)

pka

8.49±0.10(Predicted)

form 

Yellow solid.

color 

Light Yellow to Yellow

CAS DataBase Reference

6104-71-8(CAS DataBase Reference)

Safety

Hazard Codes 

Xn,T,F

Risk Statements 

20/22-36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

22-36-45-36/37-16-7

RIDADR 

3249

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N-DESMETHYLCLOZAPINE Chemical Properties,Usage,Production

Chemical Properties

Yellow Crystalline Solid

Uses

A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

Uses

N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.

Uses

A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.

Definition

ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

General Description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril^? and FrazaClo in the US. This Certified Snap-N-Spike^? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.

Biochem/physiol Actions

N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.

storage

Room temperature