N-DESMETHYLCLOZAPINE

ChemicalBook > CAS DataBase List > N-DESMETHYLCLOZAPINE

N-DESMETHYLCLOZAPINE

Product Name: N-DESMETHYLCLOZAPINE
CAS No.: 6104-71-8
Chemical Name: N-DESMETHYLCLOZAPINE
Synonyms: NORCLOZAPINE;Desmethylclozapine;Norclozapine (ACP-104);Normethylclozapine;N-DESMETHYLCLOZAPINE;Clozapine EP IMpurity C;Clozapine Impurity C（EP）;N-Desmethylclozapine solution;Norclozapine Solution, 100ppm;Desmethylclozapine (Norclozapine)
CBNumber: CB8196019
Molecular Formula: C17H17ClN4
Formula Weight: 312.8
MOL File: 6104-71-8.mol

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N-DESMETHYLCLOZAPINE Property

Melting point:: 120-125°C
Boiling point:: 502.6±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: Store at RT
solubility: Chloroform (Slightly), DMSO, Methanol (Slightly)
pka: 8.49±0.10(Predicted)
form: Yellow solid.
color: Light Yellow to Yellow
CAS DataBase Reference: 6104-71-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 20/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 22-36-45-36/37-16-7
RIDADR: 3249
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D5676
Product name: N-Desmethylclozapine
Packaging: 5mg
Price: $160
Updated: 2024/03/01

Sigma-Aldrich

Product number: D-048
Product name: N-Desmethylclozapine solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $163
Updated: 2024/03/01

Cayman Chemical

Product number: 26153
Product name: N-Desmethylclozapine
Packaging: 5mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 26153
Product name: N-Desmethylclozapine
Packaging: 100mg
Price: $1078
Updated: 2024/03/01

Sigma-Aldrich

Product number: D5676
Product name: N-Desmethylclozapine
Packaging: 10mg
Price: $237
Updated: 2024/03/01

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N-DESMETHYLCLOZAPINE Chemical Properties,Usage,Production

Chemical Properties

Yellow Crystalline Solid

Uses

A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

Uses

N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.

Uses

A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.

Definition

ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

General Description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril^? and FrazaClo in the US. This Certified Snap-N-Spike^? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.

Biochem/physiol Actions

N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.

storage

Room temperature

N-DESMETHYLCLOZAPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-DESMETHYLCLOZAPINE manufacturers

Career Henan Chemical Co

Product: N-DESMETHYLCLOZAPINE 6104-71-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

6104-71-8, N-DESMETHYLCLOZAPINERelated Search:

Prochlorperazine Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Clozapine EP IMpurity D CLOZAPINE, [N-METHYL-3H] CLOZAPINE (D4) GMC 61-39 CLOZAPINE N-OXIDE N-Desmethyl Clozapine-D8 CLOZAPINE HYDROCHLORIDE N-DESMETHYLCLOZAPINE 11,11'-(PIPERAZINE-1,4-DIYL)-BIS-8-CHLORO-5H-DIBENZE[B,E][1,4]-DIAZEPINE Clozapine

N-DESMETHYLCLOZAPINE

NORCLOZAPINE

8-CHLORO-11-(1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE

8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE

8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZEPINE

CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC

8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine

Desmethylclozapine

Normethylclozapine

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)-

Clozapine EP IMpurity C

N-Desmethylclozapine solution

N-Desmethyl Clozapine-d8 hydrochloride

8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Clozapine Impurity 3(Clozapine EP Impurity C)

Norclozapine Solution, 100ppm

NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE

3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine

Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Desmethylclozapine (Norclozapine)

8-Chloro-11-(piperazin-1-yl)-5H-dib

Clozapine EP Impurity C (N-Desmethyl Clozapine)

Norclozapine (ACP-104)

Clozapine EP Impurity CQ: What is Clozapine EP Impurity C Q: What is the CAS Number of Clozapine EP Impurity C Q: What is the storage condition of Clozapine EP Impurity C Q: What are the applications of Clozapine EP Impurity C

Clozapine Impurity C（EP）

6104-71-8

C17H17ClN4

3128

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Miscellaneous

Serotonin receptor