ChemicalBook > CAS DataBase List > 3-TROPANYL-3,5-DICHLOROBENZOATE

3-TROPANYL-3,5-DICHLOROBENZOATE

Product Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
CAS No.: 40796-97-2
Chemical Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
Synonyms: MDL-72222;MLD-72222;bemesetron;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-TROPANYL-3,5-DICHLOROBENZOATE
CBNumber: CB2317210
Molecular Formula: C15H17Cl2NO2
Formula Weight: 314.21
MOL File: 40796-97-2.mol

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3-TROPANYL-3,5-DICHLOROBENZOATE Property

Melting point:: 165 °C
Boiling point:: 406.5±45.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: 0.1 M HCl: slightly soluble
pka: 9.89±0.40(Predicted)
form: solid
color: white
Water Solubility: Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36
WGK Germany: 3
RTECS: DG7580000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 0640
Product name: MDL72222
Purity: ≥99%(HPLC)
Packaging: 50
Price: $149
Updated: 2021/12/16

TRC

Product number: M199805
Product name: MDL-72222
Packaging: 100mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: 255769
Product name: MDL 72222
Packaging: 50mg
Price: $389
Updated: 2021/12/16

ChemScene

Product number: CS-0013371
Product name: Bemesetron
Purity: >99.0%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: B6389
Product name: MDL72222
Packaging: 10mg
Price: $189
Updated: 2021/12/16

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3-TROPANYL-3,5-DICHLOROBENZOATE Chemical Properties,Usage,Production

Originator

Bemesetron,Merrel Dow

Uses

Anti-emetic.

Uses

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Manufacturing Process

Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).

Therapeutic Function

Serotonin antagonist

Biological Activity

5-HT 3 antagonist.

storage

Store at RT

3-TROPANYL-3,5-DICHLOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-TROPANYL-3,5-DICHLOROBENZOATE Suppliers

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40796-97-2, 3-TROPANYL-3,5-DICHLOROBENZOATERelated Search:

Palonosetron ALOSETRON dolasetron Dolasetron mesylate Granisetron Palonosetron Hydrochloride Palonosetron Ondansetron hydrochloride ONDANSETRON FOR LC SYSTEM SUITABILITY Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Tropine 3-TROPANYL-3,5-DICHLOROBENZOATE Nortropine hydrochloride ENDO-TROPACOCAINE (8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL) BENZOATE HCL 4-BENZYLOXY-PIPERIDINE HYDROCHLORIDE

3-TROPANYL-3,5-DICHLOROBENZOATE

MDL-72222

TROPANYL 3,5-DICHLOROBENZOATE

3,5-dichloro-,8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-benzoicaci

Bemesetron (Synonyms: MDL 72222)

Bemesetron (MDL 72222)

3,5-dichloro-benzoicaci(3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yles

bemesetron

endo-8-methyl-8-azabicyclo(3.2.1)oct-3-yl3,5-dichlorobenzoate

tropyl3,5-dichlorobenzoate

tropine 3,5-dichlorobenzoate

(1β,5β)-Tropane-3α-ol 3,5-dichlorobenzoate

3,5-Dichlorobenzoic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester

Benesetron

MLD-72222

MNJNPLVXBISNSX-WDNDVIMCSA-N

(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

Benzoic acid, 3,5-dichloro-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

rel-(1R,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

MDL 72222, 5-HT3 receptor antagonist

40796-97-2

C15H17Cl2NO2

Analytical Standards

Analytical Chromatography Product Catalog

Forensic and Veterinary Standards

Drug Standards

Chromatography

Serotonin receptor