ChemicalBook > CAS DataBase List > 3-TROPANYL-3,5-DICHLOROBENZOATE

3-TROPANYL-3,5-DICHLOROBENZOATE

Product Name
3-TROPANYL-3,5-DICHLOROBENZOATE
CAS No.
40796-97-2
Chemical Name
3-TROPANYL-3,5-DICHLOROBENZOATE
Synonyms
MDL-72222;MLD-72222;bemesetron;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-TROPANYL-3,5-DICHLOROBENZOATE
CBNumber
CB2317210
Molecular Formula
C15H17Cl2NO2
Formula Weight
314.21
MOL File
40796-97-2.mol
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3-TROPANYL-3,5-DICHLOROBENZOATE Property

Melting point:
165 °C
Boiling point:
406.5±45.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
0.1 M HCl: slightly soluble
pka
9.89±0.40(Predicted)
form 
solid
color 
white
Water Solubility 
Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36
WGK Germany 
3
RTECS 
DG7580000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J62583
Product name
3-Tropanyl-3,5-dichlorobenzoate, 99+%
Packaging
50mg
Price
$247
Updated
2021/12/16
Tocris
Product number
0640
Product name
MDL72222
Purity
≥99%(HPLC)
Packaging
50
Price
$149
Updated
2021/12/16
TRC
Product number
M199805
Product name
MDL-72222
Packaging
100mg
Price
$185
Updated
2021/12/16
Usbiological
Product number
255769
Product name
MDL 72222
Packaging
50mg
Price
$389
Updated
2021/12/16
ApexBio Technology
Product number
B6389
Product name
MDL72222
Packaging
10mg
Price
$189
Updated
2021/12/16
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3-TROPANYL-3,5-DICHLOROBENZOATE Chemical Properties,Usage,Production

Originator

Bemesetron,Merrel Dow

Uses

Anti-emetic.

Uses

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Manufacturing Process

Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).

Therapeutic Function

Serotonin antagonist

Biological Activity

5-HT 3 antagonist.

storage

Store at RT

3-TROPANYL-3,5-DICHLOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-TROPANYL-3,5-DICHLOROBENZOATE Suppliers

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40796-97-2, 3-TROPANYL-3,5-DICHLOROBENZOATERelated Search:

Palonosetron ALOSETRON dolasetron Dolasetron mesylate Granisetron Palonosetron Hydrochloride Palonosetron Ondansetron hydrochloride ONDANSETRON FOR LC SYSTEM SUITABILITY Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Tropine 3-TROPANYL-3,5-DICHLOROBENZOATE Nortropine hydrochloride ENDO-TROPACOCAINE (8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL) BENZOATE HCL 4-BENZYLOXY-PIPERIDINE HYDROCHLORIDE

  • 3-TROPANYL-3,5-DICHLOROBENZOATE
  • MDL-72222
  • TROPANYL 3,5-DICHLOROBENZOATE
  • 3,5-dichloro-,8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-benzoicaci
  • Bemesetron (Synonyms: MDL 72222)
  • Bemesetron (MDL 72222)
  • 3,5-dichloro-benzoicaci(3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yles
  • bemesetron
  • endo-8-methyl-8-azabicyclo(3.2.1)oct-3-yl3,5-dichlorobenzoate
  • tropyl3,5-dichlorobenzoate
  • tropine 3,5-dichlorobenzoate
  • (1β,5β)-Tropane-3α-ol 3,5-dichlorobenzoate
  • 3,5-Dichlorobenzoic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester
  • Benesetron
  • MLD-72222
  • MNJNPLVXBISNSX-WDNDVIMCSA-N
  • (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate
  • Benzoic acid, 3,5-dichloro-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate
  • rel-(1R,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate
  • 40796-97-2
  • C15H17Cl2NO2
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Forensic and Veterinary Standards
  • Drug Standards
  • Chromatography
  • Serotonin receptor