ChemicalBook > CAS DataBase List > AMI-193

AMI-193

Product Name: AMI-193
CAS No.: 510-74-7
Chemical Name: AMI-193
Synonyms: R 5808;AMI-193;spiramide;Fluroxyspiramine;AMI-193, 10 mM in DMSO;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
CBNumber: CB2728009
Molecular Formula: C22H26FN3O2
Formula Weight: 383.46
MOL File: 510-74-7.mol

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AMI-193 Property

Melting point:: 176 - 179°C
storage temp.: Store at RT
solubility: DMSO (Slightly), Methanol (Slightly)
form: White solid.
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 0524
Product name: AMI-193
Purity: ≥99%(HPLC)
Packaging: 10
Price: $122
Updated: 2021/12/16

Tocris

Product number: 0524
Product name: AMI-193
Purity: ≥99%(HPLC)
Packaging: 50
Price: $495
Updated: 2021/12/16

Usbiological

Product number: 254616
Product name: AMI-193
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: A576605
Product name: AMI-193
Packaging: 50mg
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-0020651
Product name: Spiramide
Purity: 98.81%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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AMI-193 Chemical Properties,Usage,Production

Uses

AMI-193 is a selective 5-HT2A and D2DR receptor antagonist. Endoplasmic reticulum (ER) stress inducer; Also, it is derived from 4-Fluorophenol (F595325), which is a fluorinated phenolic compound with various applications as an starting reagent for the synthesis of pharmaceutical goods.

Definition

ChEBI: An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spipero e but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.

Biological Activity

Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

in vivo

AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination^[2].
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments^[2].
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion)^[2].

Animal Model:	Adult male squirrel monkeys (850-1300 g)^[2]
Dosage:	0.003, 0.01 mg/kg
Administration:	I.m. on Tuesday, Wednesday, and Thursday the following week
Result:	Decreased the response rate. The rate-decreasing effects were reversed by cocaine.

IC 50

5-HT₂ Receptor: 2 nM (Ki); D₂ Receptor: 3 nM (Ki); 5-HT_1A Receptor: 50 nM (Ki); D₁ Receptor: 2530 nM (Ki); 5-HT_1C Receptor: 4300 nM (Ki)

References

[1]. czoty pw, howell ll. behavioral effects of ami-193, a 5-ht(2a)- and dopamine d(2)-receptor antagonist, in the squirrel monkey. pharmacol biochem behav, 2000, 67(2): 257-264.
[2]. ismaiel am, de los angeles j, teitler m, et al. antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-ht2- versus 5-ht1c-selective antagonist. j med chem, 1993, 36(17): 2519-2525.
[3]. luparini mr, garrone b, pazzagli m, et al. a cortical gaba-5ht interaction in the mechanism of action of the antidepressant trazodone. prog neuropsychopharmacol biol psychiatry, 2004, 28(7): 1117-1127.

AMI-193 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMI-193 Suppliers

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510-74-7, AMI-193Related Search:

Prazosin Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride 5-DECANONE [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE 4-(aminomethyl)-N,N,1-trimethylpiperidin-4-amine 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE 3-(4-fluorophenoxy)propan-1-amine CHEMBRDG-BB 4015185 AMI-193 4-(aminomethyl)-1-ethyl-N,N-dimethylpiperidin-4-amine

8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE

8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE

AMI-193

spiramide

1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one

Fluroxyspiramine

R 5808

1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-

AMI-193, 10 mM in DMSO

510-74-7

C22H26FN3O2

Serotonin receptor