H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH
H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH Basic information
- Product Name:
- H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH
- Synonyms:
-
- H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH
- H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH, (Disulfide bond between Pen2 and Cys9)
- H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH trifluoroacetate salt (Disulfide bond between Pen2 and Cys)
- H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH (Disulfide bond between Pen2 and Cys?)
- L-Alanine, glycyl-3-mercapto-L-valylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-L-cysteinyl-, cyclic (2→9)-disulfide
- Pyrrolo[2,1-g][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosine,cyclic peptide deriv
- H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH trifluoroacetate salt (Disulfide bond between Pen? and Cys?)
- H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH trifluoroacetate salt (Disulfide bond between Pen2 and Cys9)
- CAS:
- 126716-28-7
- MF:
- C35H57N13O14S2
- MW:
- 948.04
- Mol File:
- 126716-28-7.mol
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H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH Chemical Properties
- storage temp.
- -15°C
- Sequence
- Gly-{Pen}-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala (disulfide bridge:Pen2-Cys9 )
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H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH Usage And Synthesis
Uses
G-Pen-GRGDSPCA is an αvβ3-inhibiting RGD peptide. G-Pen-GRGDSPCA can limit neointimal hyperplasia and lumen stenosis after vascular injury, as well as regulate the migration and proliferation of smooth muscle cells. G-Pen-GRGDSPCA can be used in the study of the mechanism of vascular injury repair[1].
References
[1] Wei-Jun Cai, et al. Activation of the integrins alpha 5beta 1 and alpha v beta 3 and focal adhesion kinase (FAK) during arteriogenesis. Mol Cell Biochem. 2009 Feb;322(1-2):161-9. DOI:10.1007/s11010-008-9953-8
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