ARG-GLY-ASP
ARG-GLY-ASP Basic information
- Product Name:
- ARG-GLY-ASP
- Synonyms:
-
- H2N-RGD-OH
- H-ARG-GLY-ASP-OH
- L-ARG-GLY-ASP
- ARGINYL-GLYCYL-ASPARTIC ACID
- ARG-GLY-ASP
- ARG-GLY-ASP PEPTIDE
- Arg-Gly-Asp acetate
- Arginyl-glycyl-asparagilin
- CAS:
- 99896-85-2
- MF:
- C12H22N6O6
- MW:
- 346.34
- Product Categories:
-
- Peptide
- Cell Signaling Enzymes
- ECM ProteinsCytoskeleton and Extracellular Matrix
- Extracellular Matrix
- Extracellular Matrix Peptides (ECM)
- Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology
- Fibronectin Fragments and Analogs
- Matrix Metalloproteinases Products
- Various Peptides
- Mol File:
- 99896-85-2.mol
ARG-GLY-ASP Chemical Properties
- Melting point:
- 153-155℃ (ethyl ether )
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in 0.1N acetic acid at 20mg/ml
- pka
- 2.85±0.10(Predicted)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 12 mg/mL (34.64 mM) in Water
- InChIKey
- IYMAXBFPHPZYIK-BQBZGAKWSA-N
MSDS
- Language:English Provider:SigmaAldrich
ARG-GLY-ASP Usage And Synthesis
Chemical Properties
White to off-white powder
Uses
Arg-Gly-Asp has been used:
- to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
- in adhesion assay
- in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
- in textile fabrication and RGD textile functionalization
- to engineer a population of human dermal fibroblasts with impaired migration
- to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
- in the cell culture of human mammary epithelial cells
Definition
ChEBI: Arg-Gly-Asp is an oligopeptide.
General Description
Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.
Biological Activity
synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.
Biochem/physiol Actions
Primary sequence involved with the binding of proteins to cell surfaces
in vitro
rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].
in vivo
anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].
target
integrin-ligand interaction
storage
Store at -20°C
References
[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.
ARG-GLY-ASPSupplier
- Tel
- 0571-87213919
- Eric@peptidego.com
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 010-89508211 18501085097
- sales.bj@hwrkchemical.com
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
ARG-GLY-ASP(99896-85-2)Related Product Information
- L-Glutamic acid, N-(N-L-arginylglycyl)-
- H-ARG-GLY-ASP-VAL-OH
- L-ARG-GLY-ASP-SER,H-ARG-GLY-ASP-SER-OH
- THYMOPOIETIN II (32-34)
- H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH
- H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH
- H-GLY-ARG-GLY-ASP-SER-OH
- GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA
- H-ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY-OH (DISULFIDE BRIDGE: 2-10 AND 4-8)
- H-ARG-GLY-ASP-CYS-OH
- H-ARG-ARG-GLY-ASP-MET-GLU-OH
- H-GLY-ARG-GLY-ASP-THR-PRO-OH,GLY-ARG-GLY-ASP-THR-PRO
- H-GLY-ARG-GLY-ASP-ASN-PRO-OH
- SAR-ARG-GLY-ASP-SER-PRO,SAR-ARG-GLY-ASP-SER-PRO-OH
- TRP-ASN-ARG-GLN-LEU-TYR-PRO-GLU-TRP-THR-GLU-ALA-GLN-ARG-LEU-ASP
- ARG-GLY-ASP
- HIS-GLN-VAL-SER-LEU-SER-LYS-GLN-PRO-THR-SER-GLN-PRO-ARG-GLY-ASP
- H-GLY-ARG-GLY-ASP-OH