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ARG-GLY-ASP

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ARG-GLY-ASP Basic information

Product Name:
ARG-GLY-ASP
Synonyms:
  • H2N-RGD-OH
  • H-ARG-GLY-ASP-OH
  • L-ARG-GLY-ASP
  • ARGINYL-GLYCYL-ASPARTIC ACID
  • ARG-GLY-ASP
  • ARG-GLY-ASP PEPTIDE
  • Arg-Gly-Asp acetate
  • Arginyl-glycyl-asparagilin
CAS:
99896-85-2
MF:
C12H22N6O6
MW:
346.34
Product Categories:
  • Peptide
  • Cell Signaling Enzymes
  • ECM ProteinsCytoskeleton and Extracellular Matrix
  • Extracellular Matrix
  • Extracellular Matrix Peptides (ECM)
  • Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology
  • Fibronectin Fragments and Analogs
  • Matrix Metalloproteinases Products
  • Various Peptides
Mol File:
99896-85-2.mol
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ARG-GLY-ASP Chemical Properties

Melting point:
153-155℃ (ethyl ether )
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in 0.1N acetic acid at 20mg/ml
pka
2.85±0.10(Predicted)
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 12 mg/mL (34.64 mM) in Water
InChIKey
IYMAXBFPHPZYIK-BQBZGAKWSA-N
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Safety Information

WGK Germany 
3

MSDS

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ARG-GLY-ASP Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

Arg-Gly-Asp has been used:

  • to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
  • in adhesion assay
  • in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
  • in textile fabrication and RGD textile functionalization
  • to engineer a population of human dermal fibroblasts with impaired migration
  • to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
  • in the cell culture of human mammary epithelial cells

Definition

ChEBI: Arg-Gly-Asp is an oligopeptide.

General Description

Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.

Biological Activity

synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.

Biochem/physiol Actions

Primary sequence involved with the binding of proteins to cell surfaces

in vitro

rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

in vivo

anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

target

integrin-ligand interaction

storage

Store at -20°C

References

[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

ARG-GLY-ASPSupplier

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