ARG-GLY-ASP Chemical Properties

Melting point:

153-155℃ (ethyl ether )

Density 

1.61±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in 0.1N acetic acid at 20mg/ml

pka

2.85±0.10(Predicted)

form 

Powder

Water Solubility 

Soluble to 12 mg/mL (34.64 mM) in Water

InChIKey

IYMAXBFPHPZYIK-BQBZGAKWSA-N

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ARG-GLY-ASP Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

Arg-Gly-Asp has been used:

• to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
• in adhesion assay
• in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
• in textile fabrication and RGD textile functionalization
• to engineer a population of human dermal fibroblasts with impaired migration
• to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
• in the cell culture of human mammary epithelial cells

Definition

ChEBI: Arg-Gly-Asp is an oligopeptide.

General Description

Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.

Biological Activity

synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.

Biochem/physiol Actions

Primary sequence involved with the binding of proteins to cell surfaces

in vitro

rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

in vivo

anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

target

integrin-ligand interaction

storage

Store at -20°C

References

[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

ARG-GLY-ASP(99896-85-2)Related Product Information

• L-Glutamic acid, N-(N-L-arginylglycyl)-
• H-ARG-GLY-ASP-VAL-OH
• L-ARG-GLY-ASP-SER,H-ARG-GLY-ASP-SER-OH
• THYMOPOIETIN II (32-34)
• H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH
• H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH
• H-GLY-ARG-GLY-ASP-SER-OH
• GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA
• H-ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY-OH (DISULFIDE BRIDGE: 2-10 AND 4-8)
• H-ARG-GLY-ASP-CYS-OH
• H-ARG-ARG-GLY-ASP-MET-GLU-OH
• H-GLY-ARG-GLY-ASP-THR-PRO-OH,GLY-ARG-GLY-ASP-THR-PRO
• H-GLY-ARG-GLY-ASP-ASN-PRO-OH
• SAR-ARG-GLY-ASP-SER-PRO,SAR-ARG-GLY-ASP-SER-PRO-OH
• TRP-ASN-ARG-GLN-LEU-TYR-PRO-GLU-TRP-THR-GLU-ALA-GLN-ARG-LEU-ASP
• ARG-GLY-ASP
• HIS-GLN-VAL-SER-LEU-SER-LYS-GLN-PRO-THR-SER-GLN-PRO-ARG-GLY-ASP
• H-GLY-ARG-GLY-ASP-OH