GLY-ARG-GLY-ASP-SER Chemical Properties

Density 

1.66±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO : 100 mg/mL (203.89 mM);Water : 33.33 mg/mL (67.96 mM)

form 

White to off-white lyophilized solid

pka

2.85±0.10(Predicted)

color 

White to off-white

Sequence

H-Gly-Arg-Gly-Asp-Ser-OH

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GLY-ARG-GLY-ASP-SER Usage And Synthesis

Uses

Gly-Arg-Gly-Asp-Ser has been used-

• as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice
• for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1⁺ progenitor cell differentiation into SMCs (smooth muscle cells)
• as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin
• for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus

General Description

Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.

Biochem/physiol Actions

Antagonist of integrin function

GLY-ARG-GLY-ASP-SER(96426-21-0)Related Product Information

• GLY-ARG-GLY-ASP-SER-PRO-LYS,H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH,GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE
• ARG-GLY-ASP-SER
• H-GLY-ARG-GLY-ASP-SER-PRO-OH,GLY-ARG-GLY-ASP-SER-PRO
• H-GLY-ARG-GLY-ASP-SER-NH2
• CYCLO(-GLY-ARG-GLY-ASP-SER-PRO)
• DRLDS
• AC-ASP-ARG-LEU-ASP-SER-OH
• AC-ASP-ARG-GLY-ASP-SER-OH
• YRGDS
• DRGDS
• GLY-ARG-GLY-ASP-SER
• H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH
• CYCLO(-GLY-ARG-GLY-ASP-SER-PRO-ALA)
• H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH, (Disulfide bond between Pen2 and Cys9),H-GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA-OH
• GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA,gly-pen-gly-arg-gly-asp-ser-pro-cys-ala (pen2,cys
• H-GLY-ARG-GLY-ASP-SER-CYS-OH
• H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH (COUPLED TO BSA),GLY-ARG-GLY-ASP-SER-PRO-CYS
• GLY-ARG-GLY-ASP