4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Chemical Properties

Boiling point:

395℃

Density 

1.649

Flash point:

193℃

storage temp. 

Sealed in dry,Store in freezer, under -20°C

form 

solid

pka

0.53±0.70(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C8H3ClFN3O2/c9-8-4-1-7(13(14)15)5(10)2-6(4)11-3-12-8/h1-3H

InChIKey

UYQMNEZWVKRWMS-UHFFFAOYSA-N

SMILES

N1=C2C(C=C([N+]([O-])=O)C(F)=C2)=C(Cl)N=C1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Usage And Synthesis

Uses

4-Chloro-7-fluoro-6-nitroquinazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE(162012-70-6)Related Product Information

• 4-CHLORO-6-NITROQUINAZOLINE
• 4-chloro-7-fluoro-quinazoline
• 4-CHLOROQUINAZOLIN-6-AMINE
• Afatinib impurity 30
• Afatinib Impurity 22
• Afatinib Impurity L (Afatinib N-Oxide)
• Afatinib Impurity 9
• Afatinib IMpurity H
• Afatinib Impurity 74
• Afatinib impurity 40
• Afatinib impurity 33
• Afatinib Impurity 14
• TRANS-4-AMINOCROTONIC ACID
• 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
• Afatinib Impurity 17
• Afatinib Impurity 4
• Afatinib IMpurity E
• Afatinib Impurity 6