Afatinib Impurity 4 Chemical Properties

Boiling point:

513.4±50.0 °C(Predicted)

Density 

1.634±0.06 g/cm3(Predicted)

pka

5.16±0.70(Predicted)

Afatinib Impurity 4 Usage And Synthesis

Uses

N-(3,4-Dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine is a useful synthetic intermediate in the synthesis of Afatinib (A355300); an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

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