1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Basic information
- Product Name:
- 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- Synonyms:
-
- 4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-Trioxa-4-phosphaheptacosan-1-aminium 4-oxide
- NSC 324368
- NSC 343649
- Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine
- Ro 14-5243
- ET-18-OCH?
- ET-18-OCH3
- EDELFOSINE
- CAS:
- 70641-51-9
- MF:
- C27H58NO6P
- MW:
- 523.74
- Mol File:
- 70641-51-9.mol
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties
- storage temp.
- -20°C
- solubility
- ethanol: 15 mg/mL at 45 °C, soluble
- form
- waxy solid
- color
- white
- Water Solubility
- Soluble to 20 mM in water
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- YK0718000
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Usage And Synthesis
Uses
Edelfosine has been used to treat human lung carcinoma A549 cells and study its effects on tuftelin 1 (TUFT1) expression. It is also used to evaluate the cell growth of MCF-7/M cells.
Definition
ChEBI: 1-octadecyl-2-methylglycero-3-phosphocholine is a glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
General Description
Edelfosine has anti-inflammatory, anti-autoimmune, antiparasitic and anti-viral properties. It stimulates eryptosis by cell shrinkage and cell membrane scrambling.
Biochem/physiol Actions
Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity. The compound induces apoptosis in a variety of cancer cells. Edelfosine accumulates in the cell membrane, where it alters lipid composition and induces the co-clustering of lipid rafts and Fas/CD95 death receptor.
storage
Store at -20°C
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- +49 5662 408730
- info@synchem.de
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- info@creative-peptides.com
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE(70641-51-9)Related Product Information
- 1,2-DISTEAROYL-D70-3-SN-GLYCEROPHOSPHATIDYLCHOLINE
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- 1,2-Distearoyl-sn-glycero-3-phosphocholine
- 1,2-DIEICOSANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
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- 1-STEAROYL-2-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- 1,2-DINONADECANOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
- EDELFOSINE,1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- 1,2-O-DIOCTADECYL-RAC-GLYCERO-3-PHOSPHOCHOLINE
- 1-stearoyl-2-linoleoylphosphatidylcholine
- 3-O-OCTADECYL-2-O-ACETYL-SN-GLYCERO-1-PHOSPHOCHOLINE
- 1-OCTADECANOYL-2-[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE
- PAF (C18)
- 1,2-DISTEAROYL-RAC-GLYCERO-3-PHOSPHOCHOLINE
- 1,2-DIDOCOSANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- 1,2-O-DIOCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
- 1-O-OCTADECYL-2-PROPIONYL-SN-GLYCERO-3-PHOSPHOCHOLINE