1-METHOXY-9ALPHA, 11ALPHA, 15S-TRIHYDROXYPROSTA-5Z, 13E-DIENE Chemical Properties

Boiling point:

482.1±45.0 °C(Predicted)

Density 

1.056±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 7 mg/ml; DMSO: 15 mg/ml; Ethanol: 9 mg/ml; PBS (7.2): 0.16 mg/ml

pka

14.59±0.70(Predicted)

1-METHOXY-9ALPHA, 11ALPHA, 15S-TRIHYDROXYPROSTA-5Z, 13E-DIENE Usage And Synthesis

Uses

Prostaglandin F2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord[1][2][3].

Definition

ChEBI: PGF2alpha methyl ether is an aliphatic alcohol.

References

[1] Richie-Jannetta R, et al. Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):19-24. DOI:10.1016/j.prostaglandins.2010.01.003
[2] Woodward DF, et al. Recent progress in prostaglandin F2α ethanolamide (prostamide F2α) research and therapeutics. Pharmacol Rev. 2013 Jul 26;65(4):1135-47. DOI:10.1124/pr.112.007088
[3] McCracken J A, et al. Prostaglandin F2α identified as a luteolytic hormone in sheep[J]. Nature New Biology, 1972, 238(83): 129-134.

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