Basic information Safety Supplier Related

15(S)-15-Methyl prostaglandin

Basic information Safety Supplier Related

15(S)-15-Methyl prostaglandin Basic information

Product Name:
15(S)-15-Methyl prostaglandin
Synonyms:
  • 9ALPHA,11ALPHA,15S-TRIHYDROXY-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID, METHYL ESTER
  • 15(S)-15-methylProstaglandinF2amethylester
  • 15(S)-15-methylProstaglandinF2αmethylester
  • 15(S)-15-METHYL PROSTAGLANDIN
  • Carboprost methyl ester
  • Methyl (E)-7-[(1S,3S,5R)-3,5-dihydroxy-2-[(Z,3S)-3-hydroxy-3-methyloct-1-enyl]cyclopentyl]hept-5-enoate
  • U-36384
  • 15(s)15-methyl-pgf2-alphamethylester
CAS:
35700-21-1
MF:
C22H38O5
MW:
382.53
Mol File:
35700-21-1.mol
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15(S)-15-Methyl prostaglandin Chemical Properties

Melting point:
55-56°
alpha 
D +24° (c = 0.81 in ethanol)
Boiling point:
429.67°C (rough estimate)
Density 
1.0323 (rough estimate)
refractive index 
1.6120 (estimate)
storage temp. 
Store at -20°C
solubility 
DMF: >50 mg/ml (from PGE2 methyl es; DMSO: >50 mg/ml (from PGE2 methyl es; Ethanol: >50 mg/ml (from PGE2 methyl es; PBS pH 7.2: >5 mg/ml (from PGE2 methyl est
form 
A crystalline solid
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15(S)-15-Methyl prostaglandin Usage And Synthesis

Uses

15(S)-15-methyl PGF2α methyl ester is a derivative of 15(S)-15-methyl PGF2α with increased membrane permeability. Hydrolysis of the methyl ester in vivo releases the biologically active 15(S)-15-methyl PGF2α, which is a potent uterine stimulant and abortifacient.

Uses

Carboprost Methyl Ester, used in combination with Misoprostol (M368755), can boost human preadipocyte proliferation, glycerolphosphate dehrydogenase (GPDH) up-regulation and lipid accumulation during differentiation. Also, mice treated with Carboprost Methyl Ester showed termination of early pregnancy and peristatic effects. This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Definition

ChEBI: 15-methyl-15R-PGF2alpha methyl ester is a prostanoid.

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